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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rrm1  -  ribonucleotide reductase M1 polypeptide

Danio rerio

Synonyms: CHUNP6866, Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, Ribonucleotide reductase protein R1 class I, ...
 
 
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High impact information on rrm1

  • We first show that, as in mouse, lack of Otx function in zebrafish leads to transformation of the presumptive mesencephalon into an extended rhombomere 1 (r1) [1].
  • Detailed analysis of the AMH1 enhancer showed that it directs expression in the rhombomere 1 (r1) region and the dorsal thalamus, as has been shown for gbx2, whereas no expression was induced by the AMH1 enhancer in other embryonic regions in which gbx2 is expressed [2].
 

Biological context of rrm1

  • In accordance with these results, enhancer activity in the PB1-A region, as well as gbx2 expression in r1, was missing in no isthmus mutant embryos that lacked functional pax2a [2].

References

  1. Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Foucher, I., Mione, M., Simeone, A., Acampora, D., Bally-Cuif, L., Houart, C. Development (2006) [Pubmed]
  2. Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development. Islam, M.E., Kikuta, H., Inoue, F., Kanai, M., Kawakami, A., Parvin, M.S., Takeda, H., Yamasu, K. Mech. Dev. (2006) [Pubmed]
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