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Gene Review:

Rrm1 - ribonucleotide reductase M1

Mus musculus

Synonyms: Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RnrM1

Hurta, R.A. et al., Dragan, Y.P. et al., Fox, S.A. et al., Caras, I.W. et al., Mangiarotti, R. et al., et al.

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High impact information on Rrm1

Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells [1].
A series of radiation and T24-H-ras-transformed mouse 10T1/2 cell lines exhibiting increasing malignant potential was evaluated for TGF-beta 1 induced alterations in ribonucleotide reductase M1 and M2 gene expression [2].
Another gene, also located on the long arm of chromosome 1, that showed changes was the ribonucleotide reductase M1 subunit (Rrm1), in which an increase in its expression was found [3].
Bivariate flow cytometric analysis of DNA content versus immunopositivity for ribonucleotide reductase M1 subunit in the cell cycle [4].
Mapping of the ribonucleotide reductase genes (Rrm1, Rrm2) in the rat [5].

Other interactions of Rrm1

Real-time RT-PCR was used to confirm that galectin-1, the disintegrin/metalloproteinase MDC9 and ribonucleotide reductase M1 were overexpressed in AC29 B7-7 [6].

References

Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells. Caras, I.W., Martin, D.W. Mol. Cell. Biol. (1988) [Pubmed]
Early induction of ribonucleotide reductase gene expression by transforming growth factor beta 1 in malignant H-ras transformed cell lines. Hurta, R.A., Samuel, S.K., Greenberg, A.H., Wright, J.A. J. Biol. Chem. (1991) [Pubmed]
Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats. Dragan, Y.P., Sargent, L.M., Babcock, K., Kinunen, N., Pitot, H.C. Mol. Carcinog. (2004) [Pubmed]
Bivariate flow cytometric analysis of DNA content versus immunopositivity for ribonucleotide reductase M1 subunit in the cell cycle. Mangiarotti, R., Bottone, M.G., Danova, M., Pellicciari, C. Cytometry. (1998) [Pubmed]
Mapping of the ribonucleotide reductase genes (Rrm1, Rrm2) in the rat. Klinga-Levan, K., Helou, K., Issa, R., Szpirer, C., Szpirer, J., Levan, G. Mamm. Genome (1997) [Pubmed]
Identification of differentially expressed genes in murine mesothelioma cell lines of differing tumorigenicity using suppression subtractive hybridization. Fox, S.A., Loh, S., Thean, A.L., Garlepp, M.J. Biochim. Biophys. Acta (2004) [Pubmed]

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AgaP_AGAP010198	Anopheles gambiae str. PEST
RNR1	Arabidopsis thaliana
AGOS_ADL057W	Ashbya gossypii ATCC 10895
RRM1	Bos taurus
rnr-1	Caenorhabditis elegans
RRM1	Canis lupus familiaris
rrm1	Danio rerio
RnrL	Drosophila melanogaster
RRM1	Gallus gallus
RRM1	Homo sapiens
KLLA0C07887g	Kluyveromyces lactis NRRL Y-1140
RRM1	Macaca mulatta
MGG_07000	Magnaporthe oryzae 70-15
NCU03539	Neurospora crassa OR74A
Os06g0168600	Oryza sativa Japonica Group
RRM1	Pan troglodytes
Rrm1	Rattus norvegicus
RNR3	Saccharomyces cerevisiae S288c
RNR1	Saccharomyces cerevisiae S288c
cdc22	Schizosaccharomyces pombe 972h-
rrm1	Xenopus (Silurana) tropicalis

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