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Gene Review

RNR1  -  ribonucleoside-diphosphate reductase large...

Arabidopsis thaliana

Synonyms: ATRNR1, CLS8, CRINKLY LEAVES 8, DPD2, R1, ...
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  • Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair [1].
  • An Arabidopsis mutant rnr1 , which has a defect in the basic genetic system in chloroplasts, was isolated using the screening of the high chlorophyll fluorescence phenotype [2].
  • Protein R1 is the proper reductase as it contains, in the substrate binding site, the reducing active cysteine pair [3].
  • Differential responses to HgCl2 of embryo-derived explants from segregating R1 seeds of one transgenic line also were observed [4].
  • Here, we show that this role can be largely ascribed to RNR1, for which homozygous mutants germinate only on sucrose-containing media, and have white cotyledons and pale green rosette leaves [5].


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