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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RNR1  -  ribonucleoside-diphosphate reductase large...

Arabidopsis thaliana

Synonyms: ATRNR1, CLS8, CRINKLY LEAVES 8, DPD2, R1, ...
 
 
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High impact information on R1/RIBONUCLEOTIDE REDUCTASE, REDUCTASE PROTEIN R1

  • Ribonucleotide reductase (RNR), comprising two large (R1) and two small (R2) subunits, catalyzes a rate-limiting step in the production of deoxyribonucleotides needed for DNA replication and repair [1].
  • An Arabidopsis mutant rnr1 , which has a defect in the basic genetic system in chloroplasts, was isolated using the screening of the high chlorophyll fluorescence phenotype [2].
  • Protein R1 is the proper reductase as it contains, in the substrate binding site, the reducing active cysteine pair [3].
  • Differential responses to HgCl2 of embryo-derived explants from segregating R1 seeds of one transgenic line also were observed [4].
  • Here, we show that this role can be largely ascribed to RNR1, for which homozygous mutants germinate only on sucrose-containing media, and have white cotyledons and pale green rosette leaves [5].

References

  1. Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development. Wang, C., Liu, Z. Plant Cell (2006) [Pubmed]
  2. Ribosomal RNA processing and an RNase R family member in chloroplasts of Arabidopsis. Kishine, M., Takabayashi, A., Munekage, Y., Shikanai, T., Endo, T., Sato, F. Plant Mol. Biol. (2004) [Pubmed]
  3. An active ribonucleotide reductase from Arabidopsis thaliana cloning, expression and characterization of the large subunit. Sauge-Merle, S., Falconet, D., Fontecave, M. Eur. J. Biochem. (1999) [Pubmed]
  4. Transformation of peanut using a modified bacterial mercuric ion reductase gene driven by an actin promoter from Arabidopsis thaliana. Yang, H., Nairn, J., Ozias-Akins, P. J. Plant Physiol. (2003) [Pubmed]
  5. RNR1, a 3'-5' exoribonuclease belonging to the RNR superfamily, catalyzes 3' maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana. Bollenbach, T.J., Lange, H., Gutierrez, R., Erhardt, M., Stern, D.B., Gagliardi, D. Nucleic Acids Res. (2005) [Pubmed]
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