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dotB  -  defect in organelle trafficking protein...

Legionella pneumophila str. Lens

 
 
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Disease relevance of dotB

 

High impact information on dotB

  • Partial DNA sequences of the interrupted genes adjacent to the transposon insertions showed that six of them had mutations in five known L. pneumophila virulence genes: dotB, dotF/icmG, dotO/icmB, icmX, and proA [2].
  • Following encystment in Acanthamoeba castellanii and reversion of cysts to amoeba trophozoites, dotA and dotB mutants exhibited intracellular multiplication in amoebae [3].
 

Anatomical context of dotB

  • Following incubation of stationary-phase cultures in water, mutants in dotA and dotB, essential for function of the type IVB secretion system, exhibited entry and delay of phagosome acidification comparable to that of strain JR32 [3].

References

  1. Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Zamboni, D.S., McGrath, S., Rabinovitch, M., Roy, C.R. Mol. Microbiol. (2003) [Pubmed]
  2. Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia model. Edelstein, P.H., Edelstein, M.A., Higa, F., Falkow, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila. Bandyopadhyay, P., Liu, S., Gabbai, C.B., Venitelli, Z., Steinman, H.M. Infect. Immun. (2007) [Pubmed]
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