Gene Review:
Cxcl12 - chemokine (C-X-C motif) ligand 12
Mus musculus
Synonyms:
12-O-tetradecanoylphorbol 13-acetate repressed protein 1, AI174028, C-X-C motif chemokine 12, PBSF, PBSF/SDF-1, ...
- Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Avecilla, S.T., Hattori, K., Heissig, B., Tejada, R., Liao, F., Shido, K., Jin, D.K., Dias, S., Zhang, F., Hartman, T.E., Hackett, N.R., Crystal, R.G., Witte, L., Hicklin, D.J., Bohlen, P., Eaton, D., Lyden, D., de Sauvage, F., Rafii, S. Nat. Med. (2004)
- Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Nagasawa, T., Nakajima, T., Tachibana, K., Iizasa, H., Bleul, C.C., Yoshie, O., Matsushima, K., Yoshida, N., Springer, T.A., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice. Li, K., Chuen, C.K., Lee, S.M., Law, P., Fok, T.F., Ng, P.C., Li, C.K., Wong, D., Merzouk, A., Salari, H., Gu, G.J., Yuen, P.M. Stem Cells (2006)
- CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. Scimone, M.L., Felbinger, T.W., Mazo, I.B., Stein, J.V., Von Andrian, U.H., Weninger, W. J. Exp. Med. (2004)
- Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Ceradini, D.J., Kulkarni, A.R., Callaghan, M.J., Tepper, O.M., Bastidas, N., Kleinman, M.E., Capla, J.M., Galiano, R.D., Levine, J.P., Gurtner, G.C. Nat. Med. (2004)
- Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Li, G., Kataoka, H., Coughlin, S.R., Pleasure, S.J. Development (2009)
- VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Grunewald, M., Avraham, I., Dor, Y., Bachar-Lustig, E., Itin, A., Yung, S., Chimenti, S., Landsman, L., Abramovitch, R., Keshet, E. Cell (2006)
- Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Katayama, Y., Battista, M., Kao, W.M., Hidalgo, A., Peired, A.J., Thomas, S.A., Frenette, P.S. Cell (2006)
- Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N.R., Crystal, R.G., Besmer, P., Lyden, D., Moore, M.A., Werb, Z., Rafii, S. Cell (2002)
- Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. Soede, R.D., Zeelenberg, I.S., Wijnands, Y.M., Kamp, M., Roos, E. J. Immunol. (2001)
- Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Ara, T., Nakamura, Y., Egawa, T., Sugiyama, T., Abe, K., Kishimoto, T., Matsui, Y., Nagasawa, T. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Nagasawa, T., Kikutani, H., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Sweeney, E.A., Lortat-Jacob, H., Priestley, G.V., Nakamoto, B., Papayannopoulou, T. Blood (2002)
- The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Molyneaux, K.A., Zinszner, H., Kunwar, P.S., Schaible, K., Stebler, J., Sunshine, M.J., O'Brien, W., Raz, E., Littman, D., Wylie, C., Lehmann, R. Development (2003)
- Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. Tran, P.B., Ren, D., Veldhouse, T.J., Miller, R.J. J. Neurosci. Res. (2004)
- The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Egawa, T., Kawabata, K., Kawamoto, H., Amada, K., Okamoto, R., Fujii, N., Kishimoto, T., Katsura, Y., Nagasawa, T. Immunity (2001)
- Complete repair of dystrophic skeletal muscle by mesoangioblasts with enhanced migration ability. Galvez, B.G., Sampaolesi, M., Brunelli, S., Covarello, D., Gavina, M., Rossi, B., Costantin, G., Torrente, Y., Cossu, G. J. Cell Biol. (2006)
- The chemokine SDF1 controls multiple steps of myogenesis through atypical PKCzeta. Odemis, V., Boosmann, K., Dieterlen, M.T., Engele, J. J. Cell. Sci. (2007)
- Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Odemis, V., Lamp, E., Pezeshki, G., Moepps, B., Schilling, K., Gierschik, P., Littman, D.R., Engele, J. Mol. Cell. Neurosci. (2005)
- Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury. Jung, Y.J., Ryu, K.H., Cho, S.J., Woo, S.Y., Seoh, J.Y., Chun, C.H., Yoo, K., Moon, I.H., Han, H.S. Stem Cells Dev. (2006)
- Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. McGrath, K.E., Koniski, A.D., Maltby, K.M., McGann, J.K., Palis, J. Dev. Biol. (1999)
- TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytes. Han, Y., He, T., Huang, D.R., Pardo, C.A., Ransohoff, R.M. J. Clin. Invest. (2001)
- Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration. Yu, X., Huang, Y., Collin-Osdoby, P., Osdoby, P. J. Bone Miner. Res. (2003)
- A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Lieberam, I., Agalliu, D., Nagasawa, T., Ericson, J., Jessell, T.M. Neuron (2005)
- Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival. Hérodin, F., Bourin, P., Mayol, J.F., Lataillade, J.J., Drouet, M. Blood (2003)
- Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4. Mendes-da-Cruz, D.A., Silva, J.S., Cotta-de-Almeida, V., Savino, W. Eur. J. Immunol. (2006)
- Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. Tran, P.B., Banisadr, G., Ren, D., Chenn, A., Miller, R.J. J. Comp. Neurol. (2007)
- Cytokine gene expression in regenerating haematopoietic tissues of mice after cyclophosphamide treatment. Psenák, O., Sefc, L., Sýkora, V., Chang, K.T., Necas, E. Acta Haematol. (2003)