The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

lic  -  licorne

Drosophila melanogaster

Synonyms: CG12244, D-MKK3, DMEK3, DMKK3, DMKK3/lic, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on lic

  • Our phenotypic data argue for a role of lic in a post-transcriptional regulation of the grk gene [1].
  • In lic mutant egg chambers, oskar mRNA posterior localization is not properly maintained, resulting in anteroposterior patterning defects in the embryo [1].
  • Furthermore, lic loss-of-function in the germ line leads to reduced EGF receptor activity in dorsal follicle cells and ventralization of the egg shell [1].
  • Furthermore, genes that encode two novel Drosophila MAP kinase kinases, D-MKK3 and D-MKK4, were identified [2].
  • One of the responses evoked by these stimuli is the initiation of a kinase cascade that leads to the phosphorylation of p38 mitogen-activated protein (MAP) kinase on Thr and Tyr within the motif Thr-Gly-Tyr, which is located within subdomain VIII [2].

Biological context of lic

  • Activation of p38 is mediated through phosphorylation by upstream MAPKK, which in turn is activated by MAPKKK [3].
  • A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression [2].
  • The role of the p38 pathway in generation of axial polarity during oogenesis has been inferred from phenotypic analysis of mutations in the Drosophila homolog of DMKK3 [4].

Anatomical context of lic

  • p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress found in eukaryotic cells from yeast to mammals [5].

Analytical, diagnostic and therapeutic context of lic


  1. The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Suzanne, M., Irie, K., Glise, B., Agnès, F., Mori, E., Matsumoto, K., Noselli, S. Genes Dev. (1999) [Pubmed]
  2. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Han, Z.S., Enslen, H., Hu, X., Meng, X., Wu, I.H., Barrett, T., Davis, R.J., Ip, Y.T. Mol. Cell. Biol. (1998) [Pubmed]
  3. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Zhuang, Z.H., Zhou, Y., Yu, M.C., Silverman, N., Ge, B.X. Cell. Signal. (2006) [Pubmed]
  4. Stress signaling in Drosophila. Stronach, B.E., Perrimon, N. Oncogene (1999) [Pubmed]
  5. p38 MAPK signalling cascades: ancient roles and new functions. Martín-Blanco, E. Bioessays (2000) [Pubmed]
  6. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. Han, S.J., Choi, K.Y., Brey, P.T., Lee, W.J. J. Biol. Chem. (1998) [Pubmed]
WikiGenes - Universities