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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

wgn  -  wengen

Drosophila melanogaster

Synonyms: CG6531, Dmel\CG6531, TNFR, vader
 
 
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High impact information on wgn

  • The small-eye phenotype caused by an eye-specific overexpression of a Drosophila TNF superfamily ligand, Eiger, was dramatically suppressed by down-regulation of Wengen using RNA interference [1].
  • Wengen is a type III membrane protein with conserved cysteine-rich residues (TNFR homology domain) in the extracellular domain, a hallmark of the TNFR superfamily. wengen mRNA is expressed at all stages of Drosophila development [1].
  • Both Eiger and Wengen are expressed in distinctive patterns during embryogenesis and Eiger is responsive to genotoxic stress [2].
  • We also describe the isolation and characterization of a novel Drosophila member of the TNF receptor family, designated Wengen, which is a type I membrane protein that can physically interact with the recently described TRAF2 homolog dTRAF2 [2].

References

  1. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. Kanda, H., Igaki, T., Kanuka, H., Yagi, T., Miura, M. J. Biol. Chem. (2002) [Pubmed]
  2. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Kauppila, S., Maaty, W.S., Chen, P., Tomar, R.S., Eby, M.T., Chapo, J., Chew, S., Rathore, N., Zachariah, S., Sinha, S.K., Abrams, J.M., Chaudhary, P.M. Oncogene (2003) [Pubmed]
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