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Gene Review

Traf6  -  TNF-receptor-associated factor 6

Drosophila melanogaster

Synonyms: CG10961, DTRAF2, Dmel\CG10961, EP325, TRAF, ...
 
 
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Disease relevance of Traf2

 

High impact information on Traf2

  • Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways [2].
  • Collectively, our findings demonstrate that DTRAF1 and DTRAF2 play pivotal roles in Drosophila development and innate immunity by differentially regulating the JNK- and the NF-kappaB-dependent signaling pathway, respectively [2].
  • We also describe the isolation and characterization of a novel Drosophila member of the TNF receptor family, designated Wengen, which is a type I membrane protein that can physically interact with the recently described TRAF2 homolog dTRAF2 [3].
  • Vertebrate TRAFs have a very similar structure with the exception of TRAF1: aside the characteristic C-terminal TRAF domain, they share a N-terminal RING finger followed by five or, in the case of TRAF4, seven regularly spaced zinc fingers [4].
  • The Drosophila genome was found to contain three TRAF family genes: dTRAF1, dTRAF6 (dTRAF2) and a previously undescribed member we have designated dTRAF3 [5].
 

Other interactions of Traf2

  • Msn specifically binds the TRAF domain of DTRAF1 but not that of DTRAF2 [6].

References

  1. The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection. Leulier, F., Lhocine, N., Lemaitre, B., Meier, P. Mol. Cell. Biol. (2006) [Pubmed]
  2. Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Cha, G.H., Cho, K.S., Lee, J.H., Kim, M., Kim, E., Park, J., Lee, S.B., Chung, J. Mol. Cell. Biol. (2003) [Pubmed]
  3. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Kauppila, S., Maaty, W.S., Chen, P., Tomar, R.S., Eby, M.T., Chapo, J., Chew, S., Rathore, N., Zachariah, S., Sinha, S.K., Abrams, J.M., Chaudhary, P.M. Oncogene (2003) [Pubmed]
  4. Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development. Preiss, A., Johannes, B., Nagel, A.C., Maier, D., Peters, N., Wajant, H. Mech. Dev. (2001) [Pubmed]
  5. Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Grech, A., Quinn, R., Srinivasan, D., Badoux, X., Brink, R. Mol. Immunol. (2000) [Pubmed]
  6. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Liu, H., Su, Y.C., Becker, E., Treisman, J., Skolnik, E.Y. Curr. Biol. (1999) [Pubmed]
 
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