Disease relevance of TBL1X

• We postulate an involvement of TBL1 in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype [1].
• Fifteen pediatric femoral fractures in 14 patients were treated with external fixation using the EBI Orthofix unilateral external fixator [2].
• The human EBI protein has been cloned by virtue of its interaction with the C-terminus of the APC (adenomatous polyposis coli) protein, whose C-terminal truncated forms have been shown to accompany sporadic and familial forms of colorectal cancer [3].
• Fungicides which act as ergosterol biosynthesis inhibitors (EBI fungicides) such as prochloraz and propiconazole potentiate the toxicity of certain phosphorothionates to birds [4].
• Among the proteinase inhibitors, EBI, which belongs to the Bowman-Birk family of inhibitors, was cytotoxic in relatively differentiated cells such as Molt4 and Jurkat derived from acute T lymphoblastic leukemia (T-ALL) cells specifically, but ETIa and ECI, which are classified into Kunitz family inhibitors, did not [5].

Psychiatry related information on TBL1X

• Keywords used were external fixation, fracture fixation, orthopaedic or orthopaedic, limb lengthening, Ilizarov, halo traction, Orthofix, EBI fixator, pelvic fixator, ring fixator, body image, self-concept, self-esteem, self-perception, adaptation, emotional, behavior, and outcome [6].

High impact information on TBL1X

• Tbl1 gene deletion in embryonic stem cells severely impairs PPARgamma-induced adipogenic differentiation, indicating that TBL1 function is also biologically indispensable for specific nuclear receptor-mediated gene activation events [7].
• A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness [8].
• This complex contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness [8].
• By using specific small interference RNAs (siRNAs), we demonstrate that HDAC3 is essential, whereas TBL1 and TBLR1 are functionally redundant but essential for repression by unliganded thyroid hormone receptor [9].
• However, unlike OA1, TBL1 is transcribed from telomere to centromere [1].

Biological context of TBL1X

• Recently, it has been shown that TBLR1, another homologue whose gene resides on chromosome 3, and TBL1X act as a corepressor/coactivator exchanger for several nuclear receptors and transcription factors [10].
• To compare the functions of the TBL1 family, we generated a series of expression plasmids for GAL4DBD-fused proteins of the TBL1 family [10].
• Nucleotide sequence analysis revealed that 48 of these clones were derived from a single novel named EBI [11].
• A standard genome map data format for the interconnection of genome map databases was defined in collaboration with the EBI [12].
• The EBI SRS server (http://srs.ebi.ac.uk) is a free central resource for molecular biology data as well as a reference server for the latest developments in data integration [13].

Anatomical context of TBL1X

• The RT-PCR analysis of the TBL1 family revealed that TBL1Y was expressed in all 13 tissues examined but not in leukocytes [10].
• Finally, the erythroblasts enucleate and separate from the EBI [14].
• We propose that such a high degree of conservation among EBI homologs is indicative of an essential regulatory mechanism in eukaryotic cells [3].
• Cohesiveness within the EBI decreases as its associated erythroid cells mature, and the erythroblasts cease to express certain cytoadhesive molecules [14].
• Human erythropoiesis is focused near the venous sinuses of the bone marrow in EBI that are comprised of erythroblasts in intimate contact with supportive CM [14].

Associations of TBL1X with chemical compounds

• We have examined the effect of MPMAP on the alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide) (EBI) [15].
• After 1,25(OH)2D therapy, Ca2+ increased to 1.16 +/- 0.03 mmol/l in EBI and normalized in NNBI patients (1.25 +/- 0.07 mmol/l) [16].
• We have studied the effect of intravenous calcitriol [1,25(OH)2D] therapy (1 microgram at the end of each dialysis session) on parathyroid secretory curves of hemodialyzed patients with near-normal basal intact (< 10 pmol/l, n = 7; NNBI) or elevated basal intact (> 10 pmol/l, n = 6; EBI) parathyroid hormone (PTH; iPTH) levels [16].
• Mean axial stiffness was 2425 N/mm, 2358 N/mm and 2258 N/mm, respectively, for the EBI, Arthrex, and Alaron surgical plates [17].
• Functional outcome (EBI) was significantly worse in prespecified subgroups of patients: females (OR 1.46, 95% CI 1.08 to 1.98) and subjects receiving low dose tirilazad (OR 1.31, 95% CI 1.03 to 1.67); a non-significant worse outcome was also seen in patients with mild-moderate stroke (OR 1.40, 95% CI 0.99 to 1.98) [18].

Other interactions of TBL1X

• Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness [10].

Analytical, diagnostic and therapeutic context of TBL1X

• The viewer gives access to the maps of the Radiation Hybrid Database at EBI [19].
• The EBI has developed a new public database of multiple sequence alignments called EMBL-Align [20].
• Initial clinical experience with the new EBI (BARD-XT) flexible coronary stent: acute results and follow-up [21].
• Fixation was achieved with one of three fixation devices: VS Osteotomy plate (EBI, Parsippany, NJ), Arthrex Osteotomy plate (Arthrex, Naples, Fla), and OsteoTrac plate (DJ Orthopedics Inc, Vista, Calif) [17].

References