Psychiatry related information on Pgk

• Alterations in ATP metabolism likely disrupt similar pathways in humans, because PGK deficiency is associated with mental retardation, seizures, and exercise intolerance [1].

High impact information on Pgk

• Evolution of mammalian X-linked and autosomal Pgk and Pdh E1 alpha subunit genes [2].
• The Mto and Mtn cDNAs, when placed under the control of CUP1 or PGK promoters, can confer a copper-resistance phenotype to copper-hypersensitive cells [3].
• There is a single copy of Pgk in the Drosophila genome located at cytogenetic position 23A1-2 [4].
• The Pgk gene has no TATA box in the region of transcription initiation and has multiple transcription initiation sites that are closely spaced within 110 nucleotides of the translation start site [4].
• The nucleotide sequence of the Pgk gene reveals two small introns, one of which is at a position identical to the site of an intron found in Pgk genes from other organisms [4].

Associations of Pgk with chemical compounds

• Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvae [5].
• Utilizing closer-flanking markers than the previous mapping, Pgk, the structural gene for 3-phosphoglycerate kinase, has been mapped to 2-5.9; cytogenetically it was found to lie in the interval between 22D and 23E3 [6].

Other interactions of Pgk

• The nutritional conditions tested had little or no effect on the activities and transcript levels of ALD and PGK [5].

References