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Gene Review

Ald  -  Aldolase

Drosophila melanogaster

Synonyms: ALD, BcDNA:LP07735, CG6058, Dmel\CG6058, FBA, ...
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Disease relevance of Ald


High impact information on Ald


Biological context of Ald


Anatomical context of Ald

  • In contrast with the ubiquitously expressed Ald gene, Bgm expression is restricted to the tissues that are affected by X-ALD such as brain, testis and adrenals [9].

Associations of Ald with chemical compounds


Other interactions of Ald

  • The nutritional conditions tested had little or no effect on the activities and transcript levels of ALD and PGK [13].

Analytical, diagnostic and therapeutic context of Ald


  1. Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation. Kishi, H., Mukai, T., Hirono, A., Fujii, H., Miwa, S., Hori, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Alternate use of divergent forms of an ancient exon in the fructose-1,6-bisphosphate aldolase gene of Drosophila melanogaster. Kim, J., Yim, J.J., Wang, S., Dorsett, D. Mol. Cell. Biol. (1992) [Pubmed]
  3. Flight muscle function in Drosophila requires colocalization of glycolytic enzymes. Wojtas, K., Slepecky, N., von Kalm, L., Sullivan, D. Mol. Biol. Cell (1997) [Pubmed]
  4. Alternative splicing of fructose 1,6-bisphosphate aldolase transcripts in Drosophila melanogaster predicts three isozymes. Shaw-Lee, R., Lissemore, J.L., Sullivan, D.T., Tolan, D.R. J. Biol. Chem. (1992) [Pubmed]
  5. Amino acid sequence of an invertebrate FBP aldolase (from Drosophila melanogaster). Malek, A.A., Suter, F.X., Frank, G., Brenner-Holzach, O. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  6. Genetic and cytogenetic studies of four glycolytic enzymes in Drosophila melanogaster: aldolase, triosephosphate isomerase, 3-phosphoglycerate kinase, and phosphoglucomutase. Voelker, R.A., Ohnishi, S., Langley, C.H. Biochem. Genet. (1979) [Pubmed]
  7. Cloning and characterization of Schistosoma mansoni fructose-1,6-bisphosphate aldolase isoenzyme. El-Dabaa, E., Mei, H., El-Sayed, A., Karim, A.M., Eldesoky, H.M., Fahim, F.A., LoVerde, P.T., Saber, M.A. J. Parasitol. (1998) [Pubmed]
  8. Structures of cDNAs encoding the muscle-type and non-muscle-type isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes. Zhang, R., Yatsuki, H., Kusakabe, T., Iwabe, N., Miyata, T., Imai, T., Yoshida, M., Hori, K. J. Biochem. (1995) [Pubmed]
  9. Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase. Fraisl, P., Forss-Petter, S., Zigman, M., Berger, J. Biochem. J. (2004) [Pubmed]
  10. Crystallization and preliminary crystallographic data for fructose-1,6-bisphosphate aldolase from Drosophila melanogaster. Brenner-Holzach, O., Smit, J.D. J. Biol. Chem. (1982) [Pubmed]
  11. Biotin and fluorescent labeling of RNA using T4 RNA ligase. Richardson, R.W., Gumport, R.I. Nucleic Acids Res. (1983) [Pubmed]
  12. Cloning, sequencing, and characterization of the gene encoding the class I fructose-1,6-bisphosphate aldolase of Staphylococcus carnosus. Witke, C., Götz, F. J. Bacteriol. (1993) [Pubmed]
  13. Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvae. Lissemore, J.L., Baumgardner, C.A., Geer, B.W., Sullivan, D.T. Biochem. Genet. (1990) [Pubmed]
  14. Fructose 1,6-bisphosphate aldolase of Drosophila melanogaster: comparative sequence analyses around the substrate-binding lysyl residue. Brenner-Holzach, O., Zumsteg, C. Arch. Biochem. Biophys. (1982) [Pubmed]
  15. Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Duncan, R.F., Cavener, D.R., Qu, S. Biochemistry (1995) [Pubmed]
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