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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ark1  -  aurora-B kinase Ark1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on ark1

  • Having established that the initiator codon assigned to ark1(+) was incorrect and that Ark1-associated kinase activity depended upon survivin function and phosphorylation, we found that the loss of Ark1 from kinetochores by either depletion or use of a survivin mutant overides the checkpoint response to microtubule depolymerization [1].
  • We describe the cloning and characterization of the aurora-related kinase gene ark1(+), demonstrating that it is an essential gene required for sister chromatid segregation [2].

References

  1. S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response. Petersen, J., Hagan, I.M. Curr. Biol. (2003) [Pubmed]
  2. The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Leverson, J.D., Huang, H.K., Forsburg, S.L., Hunter, T. Mol. Biol. Cell (2002) [Pubmed]
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