Gene Review:
Aurka - aurora kinase A
Mus musculus
Synonyms:
AIRK1, ARK-1, AU019385, AW539821, Aik, ...
- Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Giet, R., Petretti, C., Prigent, C. Trends Cell Biol. (2005)
- Targeting Aurora kinases for the treatment of prostate cancer. Lee, E.C., Frolov, A., Li, R., Ayala, G., Greenberg, N.M. Cancer Res. (2006)
- Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Feng, L., Suzuki, M., Takeya, M., Saya, H. Oncogene (2004)
- BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. Ouchi, M., Fujiuchi, N., Sasai, K., Katayama, H., Minamishima, Y.A., Ongusaha, P.P., Deng, C., Sen, S., Lee, S.W., Ouchi, T. J. Biol. Chem. (2004)
- Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression. He, L., Yang, H., Ma, Y., Pledger, W.J., Cress, W.D., Cheng, J.Q. J. Biol. Chem. (2008)
- Chfr is required for tumor suppression and Aurora A regulation. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen, J., Chen, J. Nat. Genet. (2005)
- Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Littlepage, L.E., Ruderman, J.V. Genes Dev. (2002)
- The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Zhao, Z.S., Lim, J.P., Ng, Y.W., Lim, L., Manser, E. Mol. Cell (2005)
- Thyroid hormone regulation of thyrotropin alpha- and beta-subunit gene transcription. Gurr, J.A., Kourides, I.A. DNA (1985)
- Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. Fukuda, T., Mishina, Y., Walker, M.P., DiAugustine, R.P. Mol. Cell. Biol. (2005)
- Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Furuta, T., Baillie, D.L., Schumacher, J.M. Genesis (2002)
- Aurora-A is a critical regulator of microtubule assembly and nuclear activity in mouse oocytes, fertilized eggs, and early embryos. Yao, L.J., Zhong, Z.S., Zhang, L.S., Chen, D.Y., Schatten, H., Sun, Q.Y. Biol. Reprod. (2004)
- Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Cao, Q., Huang, Y.S., Kan, M.C., Richter, J.D. Mol. Cell. Biol. (2005)
- Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. Kimura, M.T., Mori, T., Conroy, J., Nowak, N.J., Satomi, S., Tamai, K., Nagase, H. Cancer Res. (2005)
- Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. Udayakumar, T.S., Belakavadi, M., Choi, K.H., Pandey, P.K., Fondell, J.D. J. Biol. Chem. (2006)
- Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. Jung, F.H., Pasquet, G., Lambert-van der Brempt, C., Lohmann, J.J., Warin, N., Renaud, F., Germain, H., De Savi, C., Roberts, N., Johnson, T., Dousson, C., Hill, G.B., Mortlock, A.A., Heron, N., Wilkinson, R.W., Wedge, S.R., Heaton, S.P., Odedra, R., Keen, N.J., Green, S., Brown, E., Thompson, K., Brightwell, S. J. Med. Chem. (2006)
- Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. Tseng, T.C., Chen, S.H., Hsu, Y.P., Tang, T.K. DNA Cell Biol. (1998)
- Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Mao, J.H., Wu, D., Perez-Losada, J., Jiang, T., Li, Q., Neve, R.M., Gray, J.W., Cai, W.W., Balmain, A. Cancer. Cell (2007)
- Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Hu, W., Kavanagh, J.J., Deaver, M., Johnston, D.A., Freedman, R.S., Verschraegen, C.F., Sen, S. Oncol. Res. (2005)