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Gene Review

IPL1  -  aurora kinase

Saccharomyces cerevisiae S288c

Synonyms: Aurora kinase, Increase-in-ploidy protein 1, Spindle assembly checkpoint kinase, YPL209C
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High impact information on IPL1


Biological context of IPL1

  • We investigated IPL1 function in cells that cannot replicate their chromosomes but nevertheless duplicate their spindle pole bodies (SPBs) [3].
  • We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation [4].
  • In the present study, a second human cDNA highly homologous to aurora/IPL1 (Aik2) was identified and the nucleotide sequence was determined (gene symbol STK12) [5].
  • Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules [4].
  • Ipl1p localizes to the mitotic spindle and its levels are regulated during the cell cycle [4].

Anatomical context of IPL1


Associations of IPL1 with chemical compounds

  • We have isolated a cDNA encoding a novel human protein kinase of 402 amino acids with a predicted molecular mass of 45.9 kDa, which shares high amino acid identities with the Aurora/Ipl1 protein kinase family; hence the cDNA is designated as aik (aurora/IPL1-related kinase) [7].
  • At 26 degrees C, the permissive growth temperature, ipl1 mutant cells are defective in the recovery from a transient G2/M-phase arrest caused by the antimicrotubule drug nocodazole [8].
  • Mammalian Aurora-A is related to a serine/threonine protein kinase that was originally identified by its close homology with Saccharomyces cerevisiae Ipl1p and Drosophila melanogaster aurora that are key regulators in the orchestration of mitotic events [9].
  • The Aurora kinase family is a well-characterized serine/threonine protein kinase family that regulates different processes of mitotic events [10].

Physical interactions of IPL1


Enzymatic interactions of IPL1

  • These data strongly suggest that Glc7 ensures accurate chromosome segregation by dephosphorylating Ipl1 targets rather than regulating the Ipl1 kinase [13].

Regulatory relationships of IPL1


Other interactions of IPL1


Analytical, diagnostic and therapeutic context of IPL1

  • This raises the possibility that Ipl1-Sli15 facilitates bi-orientation by promoting turnover of kinetochore-SPB connections until traction of sister kinetochores toward opposite spindle poles creates tension in the surrounding chromatin [3].


  1. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Sandall, S., Severin, F., McLeod, I.X., Yates, J.R., Oegema, K., Hyman, A., Desai, A. Cell (2006) [Pubmed]
  2. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Zhang, K., Lin, W., Latham, J.A., Riefler, G.M., Schumacher, J.M., Chan, C., Tatchell, K., Hawke, D.H., Kobayashi, R., Dent, S.Y. Cell (2005) [Pubmed]
  3. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Tanaka, T.U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M.J., Nasmyth, K. Cell (2002) [Pubmed]
  4. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Biggins, S., Severin, F.F., Bhalla, N., Sassoon, I., Hyman, A.A., Murray, A.W. Genes Dev. (1999) [Pubmed]
  5. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. Kimura, M., Matsuda, Y., Yoshioka, T., Sumi, N., Okano, Y. Cytogenet. Cell Genet. (1998) [Pubmed]
  6. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Bischoff, J.R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant, F., Ginther, C., Chan, C.S., Novotny, M., Slamon, D.J., Plowman, G.D. EMBO J. (1998) [Pubmed]
  7. Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. Kimura, M., Kotani, S., Hattori, T., Sumi, N., Yoshioka, T., Todokoro, K., Okano, Y. J. Biol. Chem. (1997) [Pubmed]
  8. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Francisco, L., Wang, W., Chan, C.S. Mol. Cell. Biol. (1994) [Pubmed]
  9. Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies. Ohashi, S., Sakashita, G., Ban, R., Nagasawa, M., Matsuzaki, H., Murata, Y., Taniguchi, H., Shima, H., Furukawa, K., Urano, T. Oncogene (2006) [Pubmed]
  10. Characterization of plant Aurora kinases during mitosis. Kawabe, A., Matsunaga, S., Nakagawa, K., Kurihara, D., Yoneda, A., Hasezawa, S., Uchiyama, S., Fukui, K. Plant Mol. Biol. (2005) [Pubmed]
  11. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Pinsky, B.A., Tatsutani, S.Y., Collins, K.A., Biggins, S. Dev. Cell (2003) [Pubmed]
  12. Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cheeseman, I.M., Anderson, S., Jwa, M., Green, E.M., Kang, J., Yates, J.R., Chan, C.S., Drubin, D.G., Barnes, G. Cell (2002) [Pubmed]
  13. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Pinsky, B.A., Kotwaliwale, C.V., Tatsutani, S.Y., Breed, C.A., Biggins, S. Mol. Cell. Biol. (2006) [Pubmed]
  14. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. Kang, J., Cheeseman, I.M., Kallstrom, G., Velmurugan, S., Barnes, G., Chan, C.S. J. Cell Biol. (2001) [Pubmed]
  15. The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Li, Y., Bachant, J., Alcasabas, A.A., Wang, Y., Qin, J., Elledge, S.J. Genes Dev. (2002) [Pubmed]
  16. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Biggins, S., Murray, A.W. Genes Dev. (2001) [Pubmed]
  17. The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase. Trautmann, S., Rajagopalan, S., McCollum, D. Dev. Cell (2004) [Pubmed]
  18. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Chan, C.S., Botstein, D. Genetics (1993) [Pubmed]
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