High impact information on morgue

• A reduction of morgue activity suppressed grim-reaper-induced cell death in Drosophila [1].
• In cultured cells, Morgue induced apoptosis that was suppressed by DIAP1 [1].
• Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis [1].
• Drosophila morgue and the intersection between protein ubiquitination and programmed cell death [2].

Biological context of morgue

• Drosophila Morgue, a ubiquitin conjugase-related protein, promotes DIAP1 down-regulation in the developing retina to permit selective programmed cell death [3].
• Interestingly, the Morgue conjugase domain lacks the active site cysteine required for covalent linkage to ubiquitin [2].

Other interactions of morgue

• Morgue may thus have a key function in apoptosis by targeting DIAP1 for ubiquitination and turnover [1].
• This gene, morgue, encodes a novel protein that contains both an F box and a ubiquitin conjugase domain [2].

References