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Gene Review

oprd1b  -  opioid receptor, delta 1b

Danio rerio

Synonyms: DOR2, SO:0000704, fb12g05, or4, wu:fb12g05
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High impact information on oprd1b

  • Functional [(35)S]guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) stimulation experiments indicate that these two peptides fully activate the zebrafish opioid receptors, although the mean effective dose (EC(50)) values obtained for ZFOR2 and ZFOR3 receptors are lower than those seen for ZFOR1 and ZFOR4 [1].
  • Pharmacological analysis of ZFOR4 shows specific and saturable binding with [(3)H] diprenorphine, displaying one binding site with K(D) = 3.42 +/- 0.38 nM and a receptor density of 6231 +/- 335 fmol/mg protein [2].
  • [(35)S]GTPgammaS stimulation studies show that the endogenous ligands Met- and Leu-enkephalin and the non-peptidic delta agonist BW373U86 were able to fully activate ZFOR4 [2].

Analytical, diagnostic and therapeutic context of oprd1b

  • In situ hybridization studies have revealed that ZFOR4 mRNA is highly expressed in particular brain areas that coincide with the expression of the delta-opioid receptor in other species [2].


  1. Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A. Gonzalez-Nu??ez, V., Marr??n Fern??ndez de Velasco, E., Arsequell, G., Valencia, G., Rodr??guez, R.E. Neuroscience (2007) [Pubmed]
  2. Characterization of a new duplicate delta-opioid receptor from zebrafish. Pinal-Seoane, N., Martin, I.R., Gonzalez-Nuñez, V., de Velasco, E.M., Alvarez, F.A., Sarmiento, R.G., Rodriguez, R.E. J. Mol. Endocrinol. (2006) [Pubmed]
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