Gene Review:
OPRD1 - opioid receptor, delta 1
Homo sapiens
Synonyms:
D-OR-1, DOR-1, Delta-type opioid receptor, OPRD
- The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Simonin, F., Befort, K., Gavériaux-Ruff, C., Matthes, H., Nappey, V., Lannes, B., Micheletti, G., Kieffer, B. Mol. Pharmacol. (1994)
- Dual signal transduction through delta opioid receptors in a transfected human T-cell line. Sharp, B.M., Shahabi, N.A., Heagy, W., McAllen, K., Bell, M., Huntoon, C., McKean, D.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression. Sharp, B.M., McAllen, K., Gekker, G., Shahabi, N.A., Peterson, P.K. J. Immunol. (2001)
- Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation. Chao, D., Donnelly, D.F., Feng, Y., Bazzy-Asaad, A., Xia, Y. J. Cereb. Blood Flow Metab. (2007)
- Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing. Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B., Bigliardi, P. Differentiation (2006)
- Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Bergen, A.W., van den Bree, M.B., Yeager, M., Welch, R., Ganjei, J.K., Haque, K., Bacanu, S., Berrettini, W.H., Grice, D.E., Goldman, D., Bulik, C.M., Klump, K., Fichter, M., Halmi, K., Kaplan, A., Strober, M., Treasure, J., Woodside, B., Kaye, W.H. Mol. Psychiatry (2003)
- Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Gelernter, J., Kranzler, H.R. Hum. Genet. (2000)
- Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. Xu, K., Liu, X.H., Nagarajan, S., Gu, X.Y., Goldman, D. Am. J. Med. Genet. (2002)
- Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis. Shen, H., Aeschlimann, A., Reisch, N., Gay, R.E., Simmen, B.R., Michel, B.A., Gay, S., Sprott, H. Arthritis Rheum. (2005)
- Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins. Alves, I.D., Ciano, K.A., Boguslavski, V., Varga, E., Salamon, Z., Yamamura, H.I., Hruby, V.J., Tollin, G. J. Biol. Chem. (2004)
- Differential sorting of human delta-opioid receptors after internalization by peptide and alkaloid agonists. Marie, N., Lecoq, I., Jauzac, P., Allouche, S. J. Biol. Chem. (2003)
- Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation. Chiu, T.T., Yung, L.Y., Wong, Y.H. Mol. Pharmacol. (1996)
- Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat). Sharp, B.M., Gekker, G., Li, M.D., Chao, C.C., Peterson, P.K. Biochem. Pharmacol. (1998)
- Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element. Hedin, K.E., Bell, M.P., Kalli, K.R., Huntoon, C.J., Sharp, B.M., McKean, D.J. J. Immunol. (1997)
- Expression of functional delta opioid receptors in vascular smooth muscle. Saeed, R.W., Stefano, G.B., Murga, J.D., Short, T.W., Qi, F., Bilfinger, T.V., Magazine, H.I. Int. J. Mol. Med. (2000)
- Modulation of postendocytic sorting of G protein-coupled receptors. Whistler, J.L., Enquist, J., Marley, A., Fong, J., Gladher, F., Tsuruda, P., Murray, S.R., Von Zastrow, M. Science (2002)
- Further Evidence of Association of OPRD1 & HTR1D Polymorphisms with Susceptibility to Anorexia Nervosa. Brown, K.M., Bujac, S.R., Mann, E.T., Campbell, D.A., Stubbins, M.J., Blundell, J.E. Biol. Psychiatry (2007)
- Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study. Gelernter, J., Gueorguieva, R., Kranzler, H.R., Zhang, H., Cramer, J., Rosenheck, R., Krystal, J.H. Alcohol. Clin. Exp. Res. (2007)
- Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. Xiang, B., Yu, G.H., Guo, J., Chen, L., Hu, W., Pei, G., Ma, L. J. Biol. Chem. (2001)
- Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Kobayashi, H., Hata, H., Ujike, H., Harano, M., Inada, T., Komiyama, T., Yamada, M., Sekine, Y., Iwata, N., Iyo, M., Ozaki, N., Itokawa, M., Naka, M., Ide, S., Ikeda, K., Numachi, Y., Sora, I. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006)
- Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. Cen, B., Yu, Q., Guo, J., Wu, Y., Ling, K., Cheng, Z., Ma, L., Pei, G. J. Neurochem. (2001)
- Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. Guo, J., Wu, Y., Zhang, W., Zhao, J., Devi, L.A., Pei, G., Ma, L. Mol. Pharmacol. (2000)
- Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors. Zhang, X., Wang, F., Chen, X., Li, J., Xiang, B., Zhang, Y.Q., Li, B.M., Ma, L. J. Neurochem. (2005)
- Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family. Zhang, S., Tong, Y., Tian, M., Dehaven, R.N., Cortesburgos, L., Mansson, E., Simonin, F., Kieffer, B., Yu, L. J. Pharmacol. Exp. Ther. (1998)
- Enkephalinergic afferents of the centromedial amygdala in the rat. Poulin, J.F., Chevalier, B., Laforest, S., Drolet, G. J. Comp. Neurol. (2006)
- Abundant expression of mu and delta opioid receptor mRNA and protein in the cerebellum of the fetal, neonatal, and adult rat. Mrkusich, E.M., Kivell, B.M., Miller, J.H., Day, D.J. Brain Res. Dev. Brain Res. (2004)
- Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor. Murray, S.R., Evans, C.J., von Zastrow, M. J. Biol. Chem. (1998)
- Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. Allen, R.M., Granger, A.L., Dykstra, L.A. J. Pharmacol. Exp. Ther. (2002)