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Chemical Compound Review

Leu-enkephalin     2-[[2-[2-[2-[[2-amino-3-(4...

Synonyms: SureCN631958, CCRIS 6338, BSPBio_002902, KBioGR_001316, KBioSS_001909, ...
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Disease relevance of Leu-enkephalin


Psychiatry related information on Leu-enkephalin


High impact information on Leu-enkephalin


Chemical compound and disease context of Leu-enkephalin


Biological context of Leu-enkephalin


Anatomical context of Leu-enkephalin


Associations of Leu-enkephalin with other chemical compounds


Gene context of Leu-enkephalin


Analytical, diagnostic and therapeutic context of Leu-enkephalin


  1. Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma. Yoshimasa, T., Nakao, K., Ohtsuki, H., Li, S., Imura, H. J. Clin. Invest. (1982) [Pubmed]
  2. Modulatory glucose effect on bombesin-like immunoreactivity and gastrin secretion from isolated perfused rat stomach. Schusdziarra, V., Schmid, R., Classen, M. Diabetes (1986) [Pubmed]
  3. Involvement of endogenous opiates in glucose-stimulated hyperinsulinism of canine endotoxin shock. Inhibition by naloxone. Merrill, G.A., Anderson, J.H. Diabetes (1987) [Pubmed]
  4. Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease. Fernandez, A., de Ceballos, M.L., Rose, S., Jenner, P., Marsden, C.D. Brain (1996) [Pubmed]
  5. Altered beta-endorphin, Met- and Leu-enkephalins, and enkephalin-containing peptides in pancreas and pituitary of genetically obese diabetic (db/db) mice during development of diabetic syndrome. Timmers, K., Voyles, N.R., Zalenski, C., Wilkins, S., Recant, L. Diabetes (1986) [Pubmed]
  6. Differential effect of posttraining naloxone, beta-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task. Netto, C.A., Dias, R.D., Izquierdo, I. Psychoneuroendocrinology (1986) [Pubmed]
  7. Central versus peripheral actions of Leu-enkephalin on acquisition of a one-way active avoidance response in rats. Martinez, J.L., Conner, P., Dana, R.C. Brain Res. (1985) [Pubmed]
  8. Retrograde amnesia caused by Met-, Leu- and des-Try-Met-enkephalin in the rat and its reversal by naloxone. Izquierdo, I., Dias, R.D. Neurosci. Lett. (1981) [Pubmed]
  9. Prolonged intermittent footshock stress decreases Met and Leu enkephalin levels in brain with concomitant decreases in pain threshold. McGivern, R.F., Mousa, S., Couri, D., Berntson, G.G. Life Sci. (1983) [Pubmed]
  10. Downregulation of enkephalin-mediated inflammatory responses by CD10/neutral endopeptidase 24.11. Shipp, M.A., Stefano, G.B., D'Adamio, L., Switzer, S.N., Howard, F.D., Sinisterra, J., Scharrer, B., Reinherz, E.L. Nature (1990) [Pubmed]
  11. Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis. Martens, G.J., Herbert, E. Nature (1984) [Pubmed]
  12. A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra. Zamir, N., Palkovits, M., Weber, E., Mezey, E., Brownstein, M.J. Nature (1984) [Pubmed]
  13. Cardiovascular effects of nociceptin in unanesthetized mice. Madeddu, P., Salis, M.B., Milia, A.F., Emanueli, C., Guerrini, R., Regoli, D., Calò, G. Hypertension (1999) [Pubmed]
  14. Effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, Papio papio. Meldrum, B.S., Menini, C., Stutzmann, J.M., Naquet, R. Brain Res. (1979) [Pubmed]
  15. Changes of central norepinephrine, beta-endorphin, LEU-enkephalin, peripheral arginine-vasopressin, and angiotensin II levels in acute and chronic phases of sino-aortic denervation in rats. Shan, Z.Z., Dai, S.M., Fang, F., Su, D.F. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  16. Relationship between vasopressin and opioids in hypoxia induced pial artery vasodilation. Rossberg, M.I., Armstead, W.M. Am. J. Physiol. (1996) [Pubmed]
  17. Leu-enkephalin, tamoxifen and ethanol interactions: effects on motility and hepatic ethanol metabolizing enzymes. Messiha, F.S. Gen. Pharmacol. (1990) [Pubmed]
  18. Met-enkephalin circulates in human plasma. Clement-Jones, V., Lowry, P.J., Rees, L.H., Besser, G.M. Nature (1980) [Pubmed]
  19. Leu-enkephalin purification from E. coli cells carrying the plasmid with fused synthetic leu-enkephalin gene. Shemyakin, M.F., Chestukhin, A.V., Dolganov, G.M., Khodkova, E.M., Monastyrskaya, G.S., Sverdlov, E.D. Nucleic Acids Res. (1980) [Pubmed]
  20. Soluble metalloendopeptidase from rat brain: action on enkephalin-containing peptides and other bioactive peptides. Chu, T.G., Orlowski, M. Endocrinology (1985) [Pubmed]
  21. Electrical properties of axons and neurohypophysial nerve terminals and their relationship to secretion in the rat. Nordmann, J.J., Stuenkel, E.L. J. Physiol. (Lond.) (1986) [Pubmed]
  22. Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design. Prokai-Tatrai, K., Prokai, L., Bodor, N. J. Med. Chem. (1996) [Pubmed]
  23. Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Wharton, J., Polak, J.M., Pearse, A.G., McGregor, G.P., Bryant, M.G., Bloom, S.R., Emson, P.C., Bisgard, G.E., Will, J.A. Nature (1980) [Pubmed]
  24. Enkephalins co-exist with oxytocin and vasopressin in nerve terminals of rat neurohypophysis. Martin, R., Voigt, K.H. Nature (1981) [Pubmed]
  25. Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum. Stern, A.S., Lewis, R.V., Kimura, S., Rossier, J., Gerber, L.D., Brink, L., Stein, S., Udenfriend, S. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  26. Ultrastructural localization and biochemical features of immunoreactive LEU-enkephalin in monkey dorsal horn. Aronin, N., DiFiglia, M., Liotta, A.S., Martin, J.B. J. Neurosci. (1981) [Pubmed]
  27. Chromostatin receptors control calcium channel activity in adrenal chromaffin cells. Galindo, E., Mendez, M., Calvo, S., Gonzalez-Garcia, C., Ceña, V., Hubert, P., Bader, M.F., Aunis, D. J. Biol. Chem. (1992) [Pubmed]
  28. Ontogeny of enkephalin and catecholamine-synthesizing enzymes in the primate fetal adrenal medulla. Wilburn, L.A., Goldsmith, P.C., Chang, K.J., Jaffe, R.B. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  29. Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb. Onali, P., Olianas, M.C. Mol. Pharmacol. (1991) [Pubmed]
  30. Topography and associations of leu-enkephalin and luteinizing hormone-releasing hormone neuronal systems in the human diencephalon. Dudás, B., Merchenthaler, I. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  31. Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin. Johnson, G.D., Stevenson, T., Ahn, K. J. Biol. Chem. (1999) [Pubmed]
  32. Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing. Fricker, L.D., Berman, Y.L., Leiter, E.H., Devi, L.A. J. Biol. Chem. (1996) [Pubmed]
  33. Gastro-intestinal and neurohormonal peptides in the alimentary tract and cerebral complex of Ciona intestinalis (Ascidiaceae). Fritsch, H.A., Van Noorden, S., Pearse, A.G. Cell Tissue Res. (1982) [Pubmed]
  34. A highly selective assay for neutral endopeptidase based on the cleavage of a fluorogenic substrate related to Leu-enkephalin. Carvalho, K.M., Boileau, G., Camargo, A.C., Juliano, L. Anal. Biochem. (1996) [Pubmed]
  35. The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leu-enkephalin on perfusion medium flow rate in the intact perfused rat adrenal. Hinson, J.P., Cameron, L.A., Purbrick, A., Kapas, S. Regul. Pept. (1994) [Pubmed]
  36. Radioimmunoassay of leucine-enkephalin-like substance in human and canine plasma. Ryder, S.W., Eng, J. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  37. Calculations on crystal packing of a flexible molecule, Leu-enkephalin. Glasser, L., Scheraga, H.A. J. Mol. Biol. (1988) [Pubmed]
  38. Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis. Maidment, N.T., Siddall, B., Rudolph, V.D., Evans, C.J. J. Neurochem. (1991) [Pubmed]
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