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Gene Review

ena  -  enabled

Drosophila melanogaster

Synonyms: CG15112, Dmel\CG15112, ENA/VASP, Ena, Enb, ...
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Disease relevance of ena


High impact information on ena

  • Genetic interactions support a model in which Abl functions to antagonize Robo signaling, while Ena is required in part for Robo's repulsive output [2].
  • Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics [3].
  • We also found that pre- but not postsynaptic gain-of-function Sema-1a was able to disrupt the GF-motor neuron synapse and that the phenotype depended on a proline-rich intracellular domain that contains a putative Enabled binding site [4].
  • Genetic interactions implicate both Enabled and Trio in LAR signal transduction [5].
  • In contrast, CAP-a Drosophila homologue of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament formation catalysed by Ena at apical cell junctions [6].

Biological context of ena


Anatomical context of ena


Associations of ena with chemical compounds


Physical interactions of ena

  • Here, we show that Ena can bind directly to the Drosophila homolog of profilin, chickadee [10].
  • Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled [11].

Enzymatic interactions of ena

  • We conclude that a critical function of Drosophila Abl is to phosphorylate and negatively regulate ena protein during neural development [16].

Other interactions of ena

  • Two prominent genes that arose from these screens were enabled (Ena) and disabled (Dab) [17].
  • This subcellular distribution is dependent on an intact Enabled/Vasp homology 1 domain, suggesting that Homer must bind to one or more of its partners for proper localization [18].


  1. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. Laurent, V., Loisel, T.P., Harbeck, B., Wehman, A., Gröbe, L., Jockusch, B.M., Wehland, J., Gertler, F.B., Carlier, M.F. J. Cell Biol. (1999) [Pubmed]
  2. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Bashaw, G.J., Kidd, T., Murray, D., Pawson, T., Goodman, C.S. Cell (2000) [Pubmed]
  3. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., Soriano, P. Cell (1996) [Pubmed]
  4. Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila. Godenschwege, T.A., Hu, H., Shan-Crofts, X., Goodman, C.S., Murphey, R.K. Nat. Neurosci. (2002) [Pubmed]
  5. Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting. Maurel-Zaffran, C., Suzuki, T., Gahmon, G., Treisman, J.E., Dickson, B.J. Neuron (2001) [Pubmed]
  6. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Baum, B., Perrimon, N. Nat. Cell Biol. (2001) [Pubmed]
  7. The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Forsthoefel, D.J., Liebl, E.C., Kolodziej, P.A., Seeger, M.A. Development (2005) [Pubmed]
  8. Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Juang, J.L., Hoffmann, F.M. Oncogene (1999) [Pubmed]
  9. Abelson kinase regulates epithelial morphogenesis in Drosophila. Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., Peifer, M. J. Cell Biol. (2001) [Pubmed]
  10. Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled. Ahern-Djamali, S.M., Bachmann, C., Hua, P., Reddy, S.K., Kastenmeier, A.S., Walter, U., Hoffmann, F.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Renfranz, P.J., Siegrist, S.E., Stronach, B.E., Macalma, T., Beckerle, M.C. Gene (2003) [Pubmed]
  12. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Martin, M., Ahern-Djamali, S.M., Hoffmann, F.M., Saxton, W.M. Mol. Biol. Cell (2005) [Pubmed]
  13. Laminin-mediated cell spreading caused integrin colocalization with intracellular signaling molecules (PAK and Ena) in a Drosophila neuronal cell line. Takagi, Y., Ui-Tei, K., Hirohashi, S. In Vitro Cell. Dev. Biol. Anim. (1999) [Pubmed]
  14. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled. Comer, A.R., Ahern-Djamali, S.M., Juang, J.L., Jackson, P.D., Hoffmann, F.M. Mol. Cell. Biol. (1998) [Pubmed]
  15. Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis. Fogerty, F.J., Juang, J.L., Petersen, J., Clark, M.J., Hoffmann, F.M., Mosher, D.F. Oncogene (1999) [Pubmed]
  16. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Gertler, F.B., Comer, A.R., Juang, J.L., Ahern, S.M., Clark, M.J., Liebl, E.C., Hoffmann, F.M. Genes Dev. (1995) [Pubmed]
  17. Filopodia formation and Disabled degradation downstream of Reelin. Winder, S.J. Biochem. J. (2004) [Pubmed]
  18. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. Diagana, T.T., Thomas, U., Prokopenko, S.N., Xiao, B., Worley, P.F., Thomas, J.B. J. Neurosci. (2002) [Pubmed]
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