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Gene Review

Ndae1  -  Na[+]-driven anion exchanger 1

Drosophila melanogaster

Synonyms: 153385_at, CG31906, CG42253, CG4675, Dmel\CG42253, ...
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High impact information on Ndae1

  • Our functional data suggest this Na(+) driven anion exchanger (NDAE1) is responsible for the Na(+)-dependent Cl(-)-HCO(3)(-) exchange activity characterized in neurons, kidney, and fibroblasts [1].
  • Moreover, our results begin to delineate the NDAE1 topology, i.e., both the NH(2) and COOH termini are intracellular [2].
  • In the present study we used immunohistochemical and Western blot techniques to characterize the developmental expression, subcellular localization, and tissue distribution of NDAE1 protein in D. melanogaster [2].
  • We have shown that a polyclonal antibody raised against the NH(2) terminus of NDAE1 (alpha CWR57) recognizes NDAE1 electrophysiologically characterized in Xenopus oocytes [2].
  • These results suggest that NDAE1 may be a key pH(i) regulatory protein and may contribute to basolateral ion transport in epithelia and nervous system of Drosophila [2].

Anatomical context of Ndae1


  1. Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. Romero, M.F., Henry, D., Nelson, S., Harte, P.J., Dillon, A.K., Sciortino, C.M. J. Biol. Chem. (2000) [Pubmed]
  2. Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster. Sciortino, C.M., Shrode, L.D., Fletcher, B.R., Harte, P.J., Romero, M.F. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
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