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Gene Review

Slc4a7  -  solute carrier family 4, sodium...

Mus musculus

Synonyms: E430014N10Rik, NBC3, NBCn1, NBCn1-G, Nbc3, ...
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Disease relevance of Slc4a7


High impact information on Slc4a7

  • Our data indicate that the USH2 proteins and NBC3 are further partners in the supramolecular USH-protein network in the retina and inner ear which shed new light on the function of USH2 proteins and the entire USH-protein network [3].
  • Precipitation of NBC3 or CFTR from transfected HEK293 cells and from the pancreas and submandibular gland also coimmunoprecipitated EBP50 [4].
  • Notably, the acinar cell NBC3 variants transported HCO3- but not OH(-) [5].
  • Functional and immunocytochemical localization of these activities in the perfused duct indicated that pNBC1 probably mediates the DIDS-sensitive/EIPA-insensitive transport in the basolateral membrane, and splice variants of NBC3 probably mediate the DIDS-insensitive/EIPA-sensitive NBC activity in the LM of duct and acinar cells [5].
  • Hence, we propose that the SLC4A10 gene product and NBCn1 both function as basolateral HCO3- entry pathways and that the SLC4A10 gene product may be responsible for the stilbene-sensitive Na+-HCO3- uptake that is essential for cerebrospinal fluid production [6].

Biological context of Slc4a7


Anatomical context of Slc4a7

  • Furthermore, the stilbene-insensitive Na+-HCO3- cotransporter, NBCn1, was also localized to the basolateral plasma membrane domain of the choroid plexus epithelium [6].
  • Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region [2].
  • NBC3 mild immunoreactivity was detected in the organ of Corti at P11 [2].
  • We conclude that NBCn1 mediates the Na+-dependent bicarbonate transport important for pH(i) regulation in smooth muscle cells of mouse mesenteric, coronary, and cerebral small arteries [7].
  • NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells [7].

Other interactions of Slc4a7

  • From P21 to P90, NBC3 expression was confined to the spiral ligament and inner and outer sulcus cells [2].

Analytical, diagnostic and therapeutic context of Slc4a7


  1. Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Bok, D., Galbraith, G., Lopez, I., Woodruff, M., Nusinowitz, S., BeltrandelRio, H., Huang, W., Zhao, S., Geske, R., Montgomery, C., Van Sligtenhorst, I., Friddle, C., Platt, K., Sparks, M.J., Pushkin, A., Abuladze, N., Ishiyama, A., Dukkipati, R., Liu, W., Kurtz, I. Nat. Genet. (2003) [Pubmed]
  2. Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7). Lopez, I.A., Acuna, D., Galbraith, G., Bok, D., Ishiyama, A., Liu, W., Kurtz, I. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  3. Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2. Reiners, J., van Wijk, E., Märker, T., Zimmermann, U., Jürgens, K., te Brinke, H., Overlack, N., Roepman, R., Knipper, M., Kremer, H., Wolfrum, U. Hum. Mol. Genet. (2005) [Pubmed]
  4. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. Park, M., Ko, S.B., Choi, J.Y., Muallem, G., Thomas, P.J., Pushkin, A., Lee, M.S., Kim, J.Y., Lee, M.G., Muallem, S., Kurtz, I. J. Biol. Chem. (2002) [Pubmed]
  5. HCO3- salvage mechanisms in the submandibular gland acinar and duct cells. Luo, X., Choi, J.Y., Ko, S.B., Pushkin, A., Kurtz, I., Ahn, W., Lee, M.G., Muallem, S. J. Biol. Chem. (2001) [Pubmed]
  6. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Praetorius, J., Nejsum, L.N., Nielsen, S. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  7. NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. Boedtkjer, E., Praetorius, J., Aalkjaer, C. Circ. Res. (2006) [Pubmed]
  8. Molecular pathophysiology of SLC4 bicarbonate transporters. Romero, M.F. Curr. Opin. Nephrol. Hypertens. (2005) [Pubmed]
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