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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CYP26C1  -  cytochrome P450, family 26, subfamily C,...

Homo sapiens

Synonyms: Cytochrome P450 26C1
 
 
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High impact information on CYP26C1

  • In this report, we describe the identification, molecular cloning, and substrate characterization of a third member of the CYP26 family, named CYP26C1 [1].
  • Competition studies with all-trans, 13-cis, and 9-cis isomers of retinoic acid demonstrated that atRA was the preferred substrate for CYP26C1 [1].
  • CYP26C1 is not widely expressed in the adult but is inducible by RA in HPK1a, transformed human keratinocyte cell lines [1].
  • BACKGROUND: CYP26A1, together with CYP26B1 and CYP26C1, are key enzymes of all-trans retinoic acid (RA) inactivation and their specific and restricted expression in developing embryos participate in the fine tuning RA levels [2].
 

Associations of CYP26C1 with chemical compounds

  • Specifically, CYP26C1 can also recognize and metabolize 9-cis-RA and is much less sensitive than the other CYP26 family members to the inhibitory effects of ketoconazole [1].
  • Throughout development CYP26A1 degrades RA in a horizontal region that extends across the retina, but during later embryonic and postnatal retina maturation this function is reinforced by another enzyme, CYP26C1 [3].

References

  1. A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. Taimi, M., Helvig, C., Wisniewski, J., Ramshaw, H., White, J., Amad, M., Korczak, B., Petkovich, M. J. Biol. Chem. (2004) [Pubmed]
  2. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. Rat, E., Billaut-Laden, I., Allorge, D., Lo-Guidice, J.M., Tellier, M., Cauffiez, C., Jonckheere, N., van Seuningen, I., Lhermitte, M., Romano, A., Guéant, J.L., Broly, F. Birth Defects Res. Part A Clin. Mol. Teratol. (2006) [Pubmed]
  3. Retinoids, eye development, and maturation of visual function. Luo, T., Sakai, Y., Wagner, E., Dräger, U.C. J. Neurobiol. (2006) [Pubmed]
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