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Gene Review:

EHI_000730 - pyrophosphate-dependent phosphofructokinase

Entamoeba histolytica HM-1:IMSS

Deng, Z. et al., O'Brien, W.E. et al., Chi, A. et al., Bruchhaus, I. et al., Huang, M. et al.

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Disease relevance of 91.t00031

Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii [1].

High impact information on 91.t00031

The pyrophosphate-dependent phosphofructokinase (PP(i)-PFK) of Entamoeba histolytica displays a million fold preference for inorganic pyrophosphate (PP(i)) over ATP (calculated as the ratio of k(cat)/K(m)) [2].
Attempts to define the active site of pyrophosphate-dependent phosphofructokinase (PPi-PFK) using homology modeling based on the three-dimensional structure of the ATP-dependent PFKs from bacteria have been frustrated by low sequence identity between PPi- and ATP-PFKs in their carboxyl terminal halves [3].
Pyrophosphate-dependent phosphofructokinase (PPi-PFK) gene from Entamoeba histolytica was cloned from its genomic library and sequenced [4].

Chemical compound and disease context of 91.t00031

A pyrophosphate-dependent phosphofructokinase (pyrophosphate; D-fructose-6-phosphate-1-phosphotransferase) has been purified and characterized from extracts of Propionibacterium shermanii [1].

Associations of 91.t00031 with chemical compounds

Site-directed mutagenesis of the fructose 6-phosphate binding site of the pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica [3].

Analytical, diagnostic and therapeutic context of 91.t00031

Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues [5].

References

Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii. O'Brien, W.E., Bowien, S., Wood, H.G. J. Biol. Chem. (1975) [Pubmed]
The primordial high energy compound: ATP or inorganic pyrophosphate? Chi, A., Kemp, R.G. J. Biol. Chem. (2000) [Pubmed]
Site-directed mutagenesis of the fructose 6-phosphate binding site of the pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica. Deng, Z., Wang, X., Kemp, R.G. Arch. Biochem. Biophys. (2000) [Pubmed]
Cloning and sequencing a putative pyrophosphate-dependent phosphofructokinase gene from Entamoeba histolytica. Huang, M., Albach, R.A., Chang, K.P., Tripathi, R.L., Kemp, R.G. Biochim. Biophys. Acta (1995) [Pubmed]
Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues. Bruchhaus, I., Jacobs, T., Denart, M., Tannich, E. Biochem. J. (1996) [Pubmed]

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