High impact information on Sur

• Mammalian SUR genes are associated with K(ATP) (ATP-sensitive potassium) channels, which are involved in metabolic homeostasis [1].
• During Drosophila embryogenesis, the Dsur gene is specifically expressed in the developing tracheal system and dorsal vessel [2].
• Studies of the Drosophila genome support that only a single Dsur gene is present [2].
• When Dsur alone is expressed in Xenopus oocytes glibenclamide-sensitive potassium channel activity occurs [2].
• The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach [2].

Associations of Sur with chemical compounds

• Our data reveal conservation of glibenclamide-sensitive potassium channels in Drosophila and suggest that Dsur may play an important role during Drosophila embryogenesis [2].
• These results support our conclusion that the sulfonylurea receptor (SUR) is the target of diflubenzuron in inhibition of chitin synthesis in these two insect species [3].

References