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Gene Review

Sur  -  Sulfonylurea receptor

Drosophila melanogaster

Synonyms: ATP-binding cassette sub-family C member Sur, BEST:CK00325, CG5772, CK00325, CYO, ...
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High impact information on Sur

  • Mammalian SUR genes are associated with K(ATP) (ATP-sensitive potassium) channels, which are involved in metabolic homeostasis [1].
  • During Drosophila embryogenesis, the Dsur gene is specifically expressed in the developing tracheal system and dorsal vessel [2].
  • Studies of the Drosophila genome support that only a single Dsur gene is present [2].
  • When Dsur alone is expressed in Xenopus oocytes glibenclamide-sensitive potassium channel activity occurs [2].
  • The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach [2].

Associations of Sur with chemical compounds


  1. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Akasaka, T., Klinedinst, S., Ocorr, K., Bustamante, E.L., Kim, S.K., Bodmer, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system. Nasonkin, I., Alikasifoglu, A., Ambrose, C., Cahill, P., Cheng, M., Sarniak, A., Egan, M., Thomas, P.M. J. Biol. Chem. (1999) [Pubmed]
  3. Significance of the sulfonylurea receptor (SUR) as the target of diflubenzuron in chitin synthesis inhibition in Drosophila melanogaster and Blattella germanica. Abo-Elghar, G.E., Fujiyoshi, P., Matsumura, F. Insect Biochem. Mol. Biol. (2004) [Pubmed]
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