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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MACC1  -  metastasis associated in colon cancer 1

Homo sapiens

Synonyms: 7A5, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, SH3BP4L
 
 
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High impact information on 7A5

  • To redirect their tropism to human T cells, MS4 cells were transfected with the expression gene encoding the scFv 7A5 in fusion with the transmembrane domain (TM) of the SNV Env protein, previously shown to retarget SNV vector particles to human lymphocytes [1].
  • The scFv 7A5 in particular was able to mediate selective transduction of human T cells with high efficiency [2].
  • The antigen detected by 7A5 was a glycoprotein consisting of 48K and 12K mol. wt. components, which were non-covalently associated with each other [3].
  • 7A5 antibody also reacted with the majority (80%) of thymocytes but neither with peripheral lymphocytes nor with bone marrow cells [3].
  • Human thymus and T cell antigens were identified by using four distinct monoclonal antibodies (MoAb), designated 2D5, 5B3, 7A5 and 9D4 [3].
 

Analytical, diagnostic and therapeutic context of 7A5

  • Western blot analysis of supernatant from the 7A5 packaging cells demonstrated incorporation of 7A5-TM into vector particles and indicated proteolytic processing of the coexpressed unmodified TM during particle formation [2].

References

  1. Targeted gene transfer to lymphocytes using murine leukaemia virus vectors pseudotyped with spleen necrosis virus envelope proteins. Engelstädter, M., Buchholz, C.J., Bobkova, M., Steidl, S., Merget-Millitzer, H., Willemsen, R.A., Stitz, J., Cichutek, K. Gene Ther. (2001) [Pubmed]
  2. Targeting human T cells by retroviral vectors displaying antibody domains selected from a phage display library. Engelstädter, M., Bobkova, M., Baier, M., Stitz, J., Holtkamp, N., Chu, T.H., Kurth, R., Dornburg, R., Buchholz, C.J., Cichutek, K. Hum. Gene Ther. (2000) [Pubmed]
  3. Four distinct antigen systems on human thymus and T cells defined by monoclonal antibodies: immunohistological and immunochemical studies. Ishii, Y., Kon, S., Takei, T., Fujimoto, J., Kikuchi, K. Clin. Exp. Immunol. (1983) [Pubmed]
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