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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAB41  -  RAB41, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-41
 
 
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High impact information on RAB41

  • In this study, we expressed a number of different Rab proteins, from Rab1 to Rab41 in PC12 cells and systematically screened them for those that are specifically localized on dense-core vesicles [1].
  • The results of PCR amplification indicated that human RAB41 is widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver [2].
  • RAB41 was composed of three exons, and it was mapped to chromosome 3q21.3 by comparing with the human genomic data [2].
  • The open reading frame of RAB41 is 636bp in length [2].
  • By genomic searching, an intronless pseudogene homologous to RAB41 at chromosome 16--RAB41P was identified at human chromosome 16q11 [2].
 

Anatomical context of RAB41

  • Through data mining, a novel human RAB41 gene was predicted and subsequently isolated from human testis [2].

References

  1. Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. Tsuboi, T., Fukuda, M. J. Cell. Sci. (2006) [Pubmed]
  2. Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P. Guo, J.H., Chen, L., Chen, S., Liu, X., Saiyin, H., Deng, Q., Zhuang, Y., Wan, B., Yu, L., Zhao, S.Y. DNA Seq. (2003) [Pubmed]
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