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Gene Review:

PFL_3126 - phospholipase C, phosphocholine-specific

Pseudomonas protegens Pf-5

Ivanov, A. et al., Aragon, V. et al., Sacherer, P. et al.

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Disease relevance of plcB

The third L. pneumophila gene, which was denoted plcA, encoded a protein that was highly homologous with a phospholipase C from Pseudomonas fluorescens [1].
Legionella pneumophila genes that encode lipase and phospholipase C activities [1].

High impact information on plcB

Extracellular protease and phospholipase C are controlled by the global regulatory gene gacA in the biocontrol strain Pseudomonas fluorescens CHA0 [2].

Chemical compound and disease context of plcB

Phospholipase C (phosphatidylcholine phosphohydrolase, EC 3.1.4.3) and lipase (EC 3.1.1.3) activities were detected in the supernatant fluid of Pseudomonas fluorescens strain D cultures [3].

Analytical, diagnostic and therapeutic context of plcB

The apparent molecular mass of the phospholipase C was 36,000 daltons when estimated by gel permeation chromatography [3].
A combination of ultrafiltration and successive chromatography through columns of Sephadex G-75 and DEAE-cellulose was used to purify the phospholipase C over 700-fold from the culture medium, with 28.5% yield [3].

References

Legionella pneumophila genes that encode lipase and phospholipase C activities. Aragon, V., Rossier, O., Cianciotto, N.P. Microbiology (Reading, Engl.) (2002) [Pubmed]
Extracellular protease and phospholipase C are controlled by the global regulatory gene gacA in the biocontrol strain Pseudomonas fluorescens CHA0. Sacherer, P., Défago, G., Haas, D. FEMS Microbiol. Lett. (1994) [Pubmed]
Characterisation of a phospholipase C produced by Pseudomonas fluorescens. Ivanov, A., Titball, R.W., Kostadinova, S. New Microbiol. (1996) [Pubmed]

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