High impact information on twe

• We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway [1].
• Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule [2].
• Phenotypic analysis of mat(2)synHB5 mutant flies revealed a complete block of meiosis in males and severe meiotic defects in females [3].
• The sterile Drosophila mutant, mat(2)synHB5, which had previously been isolated and mapped to the same genomic region as twine (35F), was found to carry a missense mutation in the twine gene [3].
• The data support a role for Tribbles in promoting proteolytic degradation of String/Cdc25, a key regulator of mitosis [4].

Biological context of twe

• Boule functions in spermatogenesis by controlling the translation of the meiotic cell division cycle 25 (Cdc25) phosphatase, Twine [5].

Anatomical context of twe

• As in the germ line, genetic studies indicate that Boule functions in the Cdc25 phosphatase pathway in the nervous system [5].
• CONCLUSIONS: In a finely tuned balance with Cdc25/String, Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed [6].

References