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Gene Review

twe  -  twine

Drosophila melanogaster

Synonyms: BG:DS02740.1, CG4965, Cdc25, Cdc25-like protein phosphatase twine, Dmel\CG4965, ...
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High impact information on twe

  • We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway [1].
  • Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule [2].
  • Phenotypic analysis of mat(2)synHB5 mutant flies revealed a complete block of meiosis in males and severe meiotic defects in females [3].
  • The sterile Drosophila mutant, mat(2)synHB5, which had previously been isolated and mapped to the same genomic region as twine (35F), was found to carry a missense mutation in the twine gene [3].
  • The data support a role for Tribbles in promoting proteolytic degradation of String/Cdc25, a key regulator of mitosis [4].

Biological context of twe


Anatomical context of twe

  • As in the germ line, genetic studies indicate that Boule functions in the Cdc25 phosphatase pathway in the nervous system [5].
  • CONCLUSIONS: In a finely tuned balance with Cdc25/String, Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed [6].


  1. Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Mata, J., Curado, S., Ephrussi, A., Rørth, P. Cell (2000) [Pubmed]
  2. Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule. Maines, J.Z., Wasserman, S.A. Nat. Cell Biol. (1999) [Pubmed]
  3. The Drosophila cdc25 homolog twine is required for meiosis. Courtot, C., Fankhauser, C., Simanis, V., Lehner, C.F. Development (1992) [Pubmed]
  4. The trouble with tribbles. Johnston, L.A. Curr. Biol. (2000) [Pubmed]
  5. Nervous system function for the testis RNA-binding protein boule in Drosophila. Joiner, M.L., Wu, C.F. J. Neurogenet. (2004) [Pubmed]
  6. Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation. Seher, T.C., Leptin, M. Curr. Biol. (2000) [Pubmed]
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