Gene Review:
Tbx3 - T-box 3
Rattus norvegicus
Synonyms:
T-box protein 3, T-box transcription factor TBX3
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Disease relevance of Tbx3
- In the present study, Tbx3, a member of the T-box family of transcription factors, was identified as an up-regulated gene by mRNA differential display in the regression (apoptosis) stage after uracil-induction of papillomatosis in the rat urinary bladder [1].
High impact information on Tbx3
- That suggests that Tbx3 is an apoptosis resistant gene rather than an apoptosis induced gene [1].
- These results indicate that Tbx3 is a negative regulator of apoptosis in bladder normal epithelial cells and suppression of Tbx3 expression causes inhibition of cell proliferation and induction of apoptosis in BC31, a rat bladder carcinoma cells [1].
- The obtained stable transfectant clones showed reduced expression of Tbx3 and much slower cell growth, as compared with mock transfectants, and many apoptotic cells were observed under normal culture conditions [1].
- We have found the rat bladder carcinoma cell line, BC31, to feature Tbx3 expression detectable by RT-PCR [1].
Biological context of Tbx3
- Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells [1].
References
- Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T. Cancer Lett. (2005) [Pubmed]
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