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Gene Review

Tbx3  -  T-box 3

Rattus norvegicus

Synonyms: T-box protein 3, T-box transcription factor TBX3
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Disease relevance of Tbx3


High impact information on Tbx3

  • That suggests that Tbx3 is an apoptosis resistant gene rather than an apoptosis induced gene [1].
  • These results indicate that Tbx3 is a negative regulator of apoptosis in bladder normal epithelial cells and suppression of Tbx3 expression causes inhibition of cell proliferation and induction of apoptosis in BC31, a rat bladder carcinoma cells [1].
  • The obtained stable transfectant clones showed reduced expression of Tbx3 and much slower cell growth, as compared with mock transfectants, and many apoptotic cells were observed under normal culture conditions [1].
  • We have found the rat bladder carcinoma cell line, BC31, to feature Tbx3 expression detectable by RT-PCR [1].

Biological context of Tbx3


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