Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

IGLC1 - immunoglobulin lambda constant 1 (Mcg marker)

Homo sapiens

Synonyms: Ig lambda-1 chain C regions

Ma, N.S., Okazaki, M. et al., Cannizzaro, L.A. et al., Zhou, J. et al., Emanuel, B.S. et al.

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Disease relevance of IGLC1

For CML, the breakpoint is distal to the IGLC genes, whereas for Burkitt lymphoma it is proximal [1].
We have performed in situ hybridization of a probe for the lambda IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-related chromosomal rearrangements with breakpoints in 22q11 [2].
Two of the three meningiomas maintained constitutional heterozygosity at the IGLC locus and another one showed no loss of heterozygosity at IGLC or D22S9 [3].

High impact information on IGLC1

We employed exon trapping and large-scale genomic sequence analysis of two bacterial artificial chromosome clones to isolate genes from the region between the IGLC and BCR in chromosome 22q11 [4].
Independent segregation analysis of the related owl monkey DNA sequences for these two genes demonstrated that both the SIS locus and the IGLC locus are localized on owl monkey chromosome 3 of karyotype VI, chromosome 3 of karyotype V, and chromosome 6 of karyotype IV [5].
Two cloned human DNA sequences specific for the SIS and IGLC genes were hybridized with DNAs from panels of rodent-owl monkey somatic cell hybrids [5].
Synteny of SIS and IGLC in owl monkeys. Evidence for karyotype evolution [5].
The study provides direct evidence for regional assignment of the IGLC gene cluster to 22q11 [1].

Biological context of IGLC1

Then, we compared constitutional and tumor genotypes from 14 cases of sporadic human meningiomas, using four polymorphic DNA probes on chromosome 22 (SIS, D22S1, D22S9, IGLC) [3].

References

In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma. Emanuel, B.S., Selden, J.R., Wang, E., Nowell, P.C., Croce, C.M. Cytogenet. Cell Genet. (1984) [Pubmed]
In situ hybridization and translocation breakpoint mapping. III. DiGeorge syndrome with partial monosomy of chromosome 22. Cannizzaro, L.A., Emanuel, B.S. Cytogenet. Cell Genet. (1985) [Pubmed]
Loss of genes on the long arm of chromosome 22 in human meningiomas. Okazaki, M., Nishisho, I., Tateishi, H., Motomura, K., Yamamoto, M., Miki, T., Hayakawa, T., Takai, S., Honjo, T., Mori, T. Mol. Biol. Med. (1988) [Pubmed]
Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Zhou, J., Fogelgren, B., Wang, Z., Roe, B.A., Biegel, J.A. Gene (2000) [Pubmed]
Synteny of SIS and IGLC in owl monkeys. Evidence for karyotype evolution. Ma, N.S. J. Hered. (1987) [Pubmed]

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