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Gene Review

argF  -  ornithine carbamoyltransferase

Pseudomonas syringae pv. phaseolicola 1448A

 
 
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Disease relevance of argF

  • The global arginine regulator ArgR controls expression of argF in Pseudomonas syringae pv. phaseolicola but is not required for the synthesis of phaseolotoxin or for the regulated expression of argK [1].
  • Inhibition of OCT in infected plants leads to chlorosis and growth inhibition [2].
 

High impact information on argF

  • This phytotoxin inhibits the enzyme ornithine carbamoyltransferase involved in arginine biosynthesis [3].
  • However, BR2R AND NPS3121 could be differentiated from each other on the basis of the RFLP patterns from restriction analysis of PCR-amplified DNA of argF, while the remaining tabaci strains had a third pattern [4].
  • Phaseolotoxin [N delta(N'-sulfo-diaminophosphinyl)-ornithyl-alanyl- homoarginine] produced by Pseudomonas syringae pv. phaseolicola, the bean halo blight pathogen, is a potent inhibitor of ornithine carbamoyltransferase (OCT) [2].
  • The gene probably originated from another organism, since it is very distantly related to the argF gene encoding the housekeeping toxin-sensitive OCT and has low G+C content compared with the bacterial genome as a whole and with other protein-coding genes from P. syringae pv. phaseolicola [5].
 

Chemical compound and disease context of argF

 

Biological context of argF

 

Associations of argF with chemical compounds

  • ROCT is encoded by argK, which is expressed coordinately with phaseolotoxin synthesis at 18 degrees C. To investigate the regulatory mechanisms of this system, null mutants were constructed for argK, argF (encoding the phaseolotoxin-sensitive OCTase [SOCT]), and amtA (encoding an amidinotransferase involved in phaseolotoxin synthesis) [8].

References

  1. The global arginine regulator ArgR controls expression of argF in Pseudomonas syringae pv. phaseolicola but is not required for the synthesis of phaseolotoxin or for the regulated expression of argK. Hernández-Flores, J.L., López-López, K., Garcidueñas-Piña, R., Jofre-Garfias, A.E., Alvarez-Morales, A. J. Bacteriol. (2004) [Pubmed]
  2. Genetic organization of a cluster of genes involved in the production of phaseolotoxin, a toxin produced by Pseudomonas syringae pv. phaseolicola. Zhang, Y., Rowley, K.B., Patil, S.S. J. Bacteriol. (1993) [Pubmed]
  3. Functional Characterization of the Gene Cluster from Pseudomonas syringae pv. phaseolicola NPS3121 Involved in Synthesis of Phaseolotoxin. Aguilera, S., López-López, K., Nieto, Y., Garcidueñas-Piña, R., Hernández-Guzmán, G., Hernández-Flores, J.L., Murillo, J., Alvarez-Morales, A. J. Bacteriol. (2007) [Pubmed]
  4. Restriction fragment length polymorphism evidence for genetic homology within a pathovar of Pseudomonas syringae. Scholz, B.K., Jakobek, J.L., Lindgren, P.B. Appl. Environ. Microbiol. (1994) [Pubmed]
  5. Origin, structure, and regulation of argK, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase in Pseudomonas syringae pv. phaseolicola, and functional expression of argK in transgenic tobacco. Hatziloukas, E., Panopoulos, N.J. J. Bacteriol. (1992) [Pubmed]
  6. Phaseolotoxin-insensitive ornithine carbamoyltransferase of Pseudomonas syringae pv. phaseolicola: basis for immunity to phaseolotoxin. Staskawicz, B.J., Panopoulos, N.J., Hoogenraad, N.J. J. Bacteriol. (1980) [Pubmed]
  7. Molecular analysis of thermoregulation of phaseolotoxin-resistant ornithine carbamoyltransferase (argK) from Pseudomonas syringae pv. phaseolicola. Rowley, K.B., Xu, R., Patil, S.S. Mol. Plant Microbe Interact. (2000) [Pubmed]
  8. In Pseudomonas syringae pv. phaseolicola, expression of the argK gene, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase, is regulated indirectly by temperature and directly by a precursor resembling carbamoylphosphate. López-López, K., Hernández-Flores, J.L., Cruz-Aguilar, M., Alvarez-Morales, A. J. Bacteriol. (2004) [Pubmed]
 
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