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Chemical Compound Review

AC1NUWCY     (2S)-2-[[(2S)-2-[[(2S)-2- amino-5-[[amino...

Synonyms: CTK2F4838
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Disease relevance of C08440


High impact information on C08440


Biological context of C08440

  • The isolates were classified as race 5, and their analysis revealed that they do not carry the argK-tox gene cluster involved in the biosynthesis of the phaseolotoxin [6].
  • Pseudomonas syringae pv. phaseolicola genomic clones harboring heterologous DNA sequences suppress the same phaseolotoxin-deficient mutants [7].
  • Genes involved in the production of phaseolotoxin by Pseudomonas syringae pv. "phaseolicola" NPS3121 were identified by Tn5 mutagenesis and cosmid cloning [8].
  • We confirmed that the latter is also resistant to phaseolotoxin and possesses ROCT, and we compared the two pathovars by using sequence data of the ROCT gene and the intergenic spacer region located between the 16S and 23S rRNA genes (16S-23S spacer region) as an index [9].
  • The phtE locus in the phaseolotoxin gene cluster has ORFs with homologies to genes encoding amino acid transferases, the AraC family of transcriptional factors, and fatty acid desaturases [10].

Associations of C08440 with other chemical compounds

  • These data suggest that ORF3 encodes a protein involved in the biosynthesis of ornithine, a constituent of phaseolotoxin [10].
  • Furthermore, expression of the amtA and argK genes and phaseolotoxin production occurs at 18 degrees C but not at 28 degrees C. An amidinotransferase insertion mutant was obtained that lost the capacity to synthesize homoarginine and phaseolotoxin [11].

Gene context of C08440


Analytical, diagnostic and therapeutic context of C08440

  • These Tox(-) isolates appear to lack the entire DNA region for the biosynthesis of phaseolotoxin (argK-tox gene cluster), as shown by PCR amplification and DNA hybridization using DNA sequences specific for separated genes of this cluster [16].


  1. Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. Langley, D.B., Templeton, M.D., Fields, B.A., Mitchell, R.E., Collyer, C.A. J. Biol. Chem. (2000) [Pubmed]
  2. The inhibition of ornithine transcarbamoylase from Escherichia coli W by phaseolotoxin. Templeton, M.D., Sullivan, P.A., Shepherd, M.G. Biochem. J. (1984) [Pubmed]
  3. Phaseolotoxin transport in Escherichia coli and Salmonella typhimurium via the oligopeptide permease. Staskawicz, B.J., Panopoulos, N.J. J. Bacteriol. (1980) [Pubmed]
  4. Multiple copies of a DNA sequence from Pseudomonas syringae pathovar phaseolicola abolish thermoregulation of phaseolotoxin production. Rowley, K.B., Clements, D.E., Mandel, M., Humphreys, T., Patil, S.S. Mol. Microbiol. (1993) [Pubmed]
  5. Functional Characterization of the Gene Cluster from Pseudomonas syringae pv. phaseolicola NPS3121 Involved in Synthesis of Phaseolotoxin. Aguilera, S., López-López, K., Nieto, Y., Garcidueñas-Piña, R., Hernández-Guzmán, G., Hernández-Flores, J.L., Murillo, J., Alvarez-Morales, A. J. Bacteriol. (2007) [Pubmed]
  6. Analysis of the argK-tox gene cluster in nontoxigenic strains of Pseudomonas syringae pv. phaseolicola. González, A.I., Pérez de la Vega, M., Ruiz, M.L., Polanco, C. Appl. Environ. Microbiol. (2003) [Pubmed]
  7. Pseudomonas syringae pv. phaseolicola genomic clones harboring heterologous DNA sequences suppress the same phaseolotoxin-deficient mutants. Kamdar, H.V., Rowley, K.B., Clements, D., Patil, S.S. J. Bacteriol. (1991) [Pubmed]
  8. Identification and cloning of genes involved in phaseolotoxin production by Pseudomonas syringae pv. "phaseolicola". Peet, R.C., Lindgren, P.B., Willis, D.K., Panopoulos, N.J. J. Bacteriol. (1986) [Pubmed]
  9. Comparative analysis of Pseudomonas syringae pv. actinidiae and pv. phaseolicola based on phaseolotoxin-resistant ornithine carbamoyltransferase gene (argK) and 16S-23S rRNA intergenic spacer sequences. Sawada, H., Takeuchi, T., Matsuda, I. Appl. Environ. Microbiol. (1997) [Pubmed]
  10. The phtE locus in the phaseolotoxin gene cluster has ORFs with homologies to genes encoding amino acid transferases, the AraC family of transcriptional factors, and fatty acid desaturases. Zhang, Y.X., Patil, S.S. Mol. Plant Microbe Interact. (1997) [Pubmed]
  11. Isolation and characterization of the gene coding for the amidinotransferase involved in the biosynthesis of phaseolotoxin in Pseudomonas syringae pv. phaseolicola. Hernández-Guzmán, G., Alvarez-Morales, A. Mol. Plant Microbe Interact. (2001) [Pubmed]
  12. In Pseudomonas syringae pv. phaseolicola, expression of the argK gene, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase, is regulated indirectly by temperature and directly by a precursor resembling carbamoylphosphate. López-López, K., Hernández-Flores, J.L., Cruz-Aguilar, M., Alvarez-Morales, A. J. Bacteriol. (2004) [Pubmed]
  13. The global arginine regulator ArgR controls expression of argF in Pseudomonas syringae pv. phaseolicola but is not required for the synthesis of phaseolotoxin or for the regulated expression of argK. Hernández-Flores, J.L., López-López, K., Garcidueñas-Piña, R., Jofre-Garfias, A.E., Alvarez-Morales, A. J. Bacteriol. (2004) [Pubmed]
  14. Inhibition of ornithine carbamoyltransferase from Pseudomonas syringae pv. syringae W50 by phaseolotoxin. Jahn, O., Sauerstein, J., Reuter, G. J. Basic Microbiol. (1989) [Pubmed]
  15. Influence of phaseolotoxin on the alkaloid accumulation in Datura innoxia Mill. Missaleva, N., Petri, G., Reuter, G., Szöke, E., Markish, U. Acta pharmaceutica Hungarica. (1993) [Pubmed]
  16. Pseudomonas syringae pv. phaseolicola can be separated into two genetic lineages distinguished by the possession of the phaseolotoxin biosynthetic cluster. Oguiza, J.A., Rico, A., Rivas, L.A., Sutra, L., Vivian, A., Murillo, J. Microbiology (Reading, Engl.) (2004) [Pubmed]
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