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Gene Review

RhoGEF2  -  Rho guanine nucleotide exchange factor 2

Drosophila melanogaster

Synonyms: CG9635, DRhoGEF, DRhoGEF2, Dmel\CG9635, DrhoGEF2, ...
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Disease relevance of RhoGEF2

  • In embryos from RhoGEF2 or dia germline clones, furrow canals do not form at all or are considerably enlarged and contain cytoplasmic blebs [1].

High impact information on RhoGEF2

  • The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation [2].
  • Evidence is also presented that DRhoGEF2 mediates these specific cell shape changes in response to the extracellular ligand, Fog [2].
  • In a genetic screen for Rho signaling pathway components in Drosophila, we identified a gene, DRhoGEF2, that encodes a predicted Rho-specific guanine nucleotide exchange factor [2].
  • In addition to its previously identified role involving RhoGEF-1 in migrating cells and growth cones, our data indicate that UNC-73 signals through RhoGEF-2 to regulate pharynx and vulva musculature and to modulate synaptic neurotransmission [3].
  • DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila [4].

Biological context of RhoGEF2


Anatomical context of RhoGEF2


Regulatory relationships of RhoGEF2

  • Further, RhoGEF2 also regulates ordered actin localization during ventral furrow formation, whereas its activator, Cta, does not [11].

Other interactions of RhoGEF2


Analytical, diagnostic and therapeutic context of RhoGEF2

  • DRhoGEF2 exerts its effects in gastrulation through the regulation of Myosin II to orchestrate coordinated apical cell constriction [14].


  1. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Grosshans, J., Wenzl, C., Herz, H.M., Bartoszewski, S., Schnorrer, F., Vogt, N., Schwarz, H., Müller, H.A. Development (2005) [Pubmed]
  2. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Barrett, K., Leptin, M., Settleman, J. Cell (1997) [Pubmed]
  3. The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. Steven, R., Zhang, L., Culotti, J., Pawson, T. Genes Dev. (2005) [Pubmed]
  4. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Häcker, U., Perrimon, N. Genes Dev. (1998) [Pubmed]
  5. DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. Padash Barmchi, M., Rogers, S., Häcker, U. J. Cell Biol. (2005) [Pubmed]
  6. Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Sim??es, S., Denholm, B., Azevedo, D., Sotillos, S., Martin, P., Skaer, H., Hombr??a, J.C., Jacinto, A. Development (2006) [Pubmed]
  7. Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF. Oleksy, A., Barton, H., Devedjiev, Y., Purdy, M., Derewenda, U., Otlewski, J., Derewenda, Z.S. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  8. The pebble GTP exchange factor and the control of cytokinesis. O'Keefe, L., Somers, W.G., Harley, A., Saint, R. Cell Struct. Funct. (2001) [Pubmed]
  9. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Rogers, S.L., Wiedemann, U., Häcker, U., Turck, C., Vale, R.D. Curr. Biol. (2004) [Pubmed]
  10. Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2. Kölsch, V., Seher, T., Fernandez-Ballester, G.J., Serrano, L., Leptin, M. Science (2007) [Pubmed]
  11. Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Fox, D.T., Peifer, M. Development (2007) [Pubmed]
  12. folded gastrulation, cell shape change and the control of myosin localization. Dawes-Hoang, R.E., Parmar, K.M., Christiansen, A.E., Phelps, C.B., Brand, A.H., Wieschaus, E.F. Development (2005) [Pubmed]
  13. A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Somers, W.G., Saint, R. Dev. Cell (2003) [Pubmed]
  14. A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation. Nikolaidou, K.K., Barrett, K. Curr. Biol. (2004) [Pubmed]
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