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Gene Review

BIM1  -  Bim1p

Saccharomyces cerevisiae S288c

Synonyms: Protein BIM1, YER016W
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Disease relevance of BIM1

  • Deletion of BIM1 results in a strong bilateral karyogamy defect, hypersensitivity to benomyl, and aberrant spindle behavior, all phenotypes associated with mutations affecting microtubules in yeast, and inviability at extreme temperatures (i.e., >/=37 degrees C or </=14 degrees C) [1].
  • Bim1 homolog EB1 was originally identified through its interaction with adenomatous polyposis coli (APC) tumor suppressor, raising the possibility that an APC-EB1 linkage orients microtubules in higher cells [2].

High impact information on BIM1

  • Here, we show that Kar9 directs microtubule orientation by acting through Bim1, a conserved microtubule-binding protein [2].
  • We examined the regulation of the proapoptotic activity of the BH3-only protein Bim [3].
  • During G1, microtubules in cells lacking BIM1 showed reduced dynamicity due to a slower shrinkage rate, fewer rescues and catastrophes, and more time spent in an attenuated/paused state [4].
  • Here we investigate the physical and functional interactions among three +TIPs in S. cerevisiae, Stu2, Bik1, and Bim1 [5].
  • Here, we show that deletion of four C-terminal residues of the budding yeast gamma-tubulin Tub4 (tub4-Deltadsyl) perturbs Bim1 and Kar9 localization to SPBs and Kar9-dependant spindle positioning [6].

Biological context of BIM1


Anatomical context of BIM1


Physical interactions of BIM1

  • These experiments demonstrate that the interaction of cytoplasmic microtubules with the Kar9p cortical attachment site requires the microtubule-binding protein Bim1p [8].

Other interactions of BIM1

  • PKC1, a protein kinase C homologue of Saccharomyces cerevisiae, participates in microtubule function through the yeast EB1 homologue, BIM1 [7].
  • These assays additionally implicated three proteins, Bim1, Ump1, and YKL171W, in proteasome function [9].
  • Two-hybrid, coimmunoprecipitation, and in vitro binding assays demonstrate that they associate in all pairwise combinations, although the interaction between Stu2 and Bim1 may be indirect [5].


  1. BIM1 encodes a microtubule-binding protein in yeast. Schwartz, K., Richards, K., Botstein, D. Mol. Biol. Cell (1997) [Pubmed]
  2. Molecular linkage underlying microtubule orientation toward cortical sites in yeast. Korinek, W.S., Copeland, M.J., Chaudhuri, A., Chant, J. Science (2000) [Pubmed]
  3. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Puthalakath, H., Huang, D.C., O'Reilly, L.A., King, S.M., Strasser, A. Mol. Cell (1999) [Pubmed]
  4. Yeast Bim1p promotes the G1-specific dynamics of microtubules. Tirnauer, J.S., O'Toole, E., Berrueta, L., Bierer, B.E., Pellman, D. J. Cell Biol. (1999) [Pubmed]
  5. The regulation of microtubule dynamics in Saccharomyces cerevisiae by three interacting plus-end tracking proteins. Wolyniak, M.J., Blake-Hodek, K., Kosco, K., Hwang, E., You, L., Huffaker, T.C. Mol. Biol. Cell (2006) [Pubmed]
  6. {gamma}-Tubulin Is Required for Proper Recruitment and Assembly of Kar9-Bim1 Complexes in Budding Yeast. Cuschieri, L., Miller, R., Vogel, J. Mol. Biol. Cell (2006) [Pubmed]
  7. PKC1, a protein kinase C homologue of Saccharomyces cerevisiae, participates in microtubule function through the yeast EB1 homologue, BIM1. Hosotani, T., Koyama, H., Uchino, M., Miyakawa, T., Tsuchiya, E. Genes Cells (2001) [Pubmed]
  8. Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules. Miller, R.K., Cheng, S.C., Rose, M.D. Mol. Biol. Cell (2000) [Pubmed]
  9. Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Cagney, G., Uetz, P., Fields, S. Physiol. Genomics (2001) [Pubmed]
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