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Gene Review

Klp10A  -  Kinesin-like protein at 10A

Drosophila melanogaster

Synonyms: CG1453, DmCG1453, DmKLP10A, DmKlp10A, Dmel\CG1453, ...
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High impact information on Klp10A

  • Analyses of microtubule dynamics in S2 cells depleted of these proteins indicate that both proteins stimulate depolymerization, but alter distinct parameters of dynamic instability; KLP10A stimulates catastrophe (a switch from growth to shrinkage) whereas KLP59C suppresses rescue (a switch from shrinkage to growth) [1].
  • Our data also suggest that KLP10A is deposited on microtubules by the plus-end tracking protein, EB1 [1].
  • Moreover, immunofluorescence and live analyses of cells expressing tagged kinesins reveal that KLP10A and KLP59C target to polymerizing and depolymerizing microtubule plus ends, respectively [1].
  • Klp10A, concentrated on microtubule plus ends in interphase and prophase, relocalizes to centromeres and spindle poles upon NEB and remains at these sites throughout anaphase [2].
  • RNAi depletion of the abnormal spindle protein, Asp, which localizes to focused poles of control spindles, produced a severe loss of spindle pole focus, whereas depletion of the pole-associated microtubule depolymerase KLP10A increased spindle microtubule density [3].

Biological context of Klp10A


Other interactions of Klp10A

  • We conclude that Klp10A exclusively antagonises Orbit in the regulation of bipolar spindle formation and maintenance [4].


  1. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Mennella, V., Rogers, G.C., Rogers, S.L., Buster, D.W., Vale, R.D., Sharp, D.J. Nat. Cell Biol. (2005) [Pubmed]
  2. Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells. Goshima, G., Vale, R.D. Mol. Biol. Cell (2005) [Pubmed]
  3. Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A. Morales-Mulia, S., Scholey, J.M. Mol. Biol. Cell (2005) [Pubmed]
  4. Antagonistic activities of Klp10A and Orbit regulate spindle length, bipolarity and function in vivo. Laycock, J.E., Savoian, M.S., Glover, D.M. J. Cell. Sci. (2006) [Pubmed]
  5. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Rogers, G.C., Rogers, S.L., Schwimmer, T.A., Ems-McClung, S.C., Walczak, C.E., Vale, R.D., Scholey, J.M., Sharp, D.J. Nature (2004) [Pubmed]
  6. KLP10A and KLP59C: the dynamic duo of microtubule depolymerization. Sharp, D.J., Mennella, V., Buster, D.W. Cell Cycle (2005) [Pubmed]
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