High impact information on Pgi

• The enzymes catalyzing near-equilibrium reactions, phosphoglucose isomerase, phosphoglucomutase, and triosephosphate isomerase fail to show any decline in flight performance even when activity levels are reduced to 17% or less [1].
• We find that mmy encodes the UDP-N-acetylglucosamine pyrophosphorylase, which catalyses the production of UDP-N-acetylglucosamine, an obligate substrate for chitin synthases as well as for protein glycosylation and GPI-anchor formation [2].
• We show that Knk is an apical GPI-linked protein that acts at the plasma membrane [3].
• By immunological techniques, two natural null variants of malic enzyme and one of phosphoglucose isomerase were shown to be negative to cross-reacting material [4].
• These phenotypes correlate well with specific glycosylation and GPI-anchorage defects in mummy mutants [5].

Anatomical context of Pgi

• In addition, the glycosylation pathway is required to generate GPI-linkage in the endoplasmatic reticulum [5].

Other interactions of Pgi

• The HKA test, which tests imbalance between the intra and interspecific nucleotide variation, showed that the intraspecific nucleotide variation in the Pgi region was much lower than the interspecific variation, while intraspecific variation in the Tpi region was only slightly lower than interspecific variation [6].

References