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Gene Review

babo  -  baboon

Drosophila melanogaster

Synonyms: ATR-1, ATR-I, Atf1, Atr-1, Atr-I, ...
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High impact information on babo

  • Genetic analysis of babo loss-of-function mutants and ectopic activation studies indicate that Babo signaling plays a role in regulating cell proliferation [1].
  • Null mutants of daw, as well as mutations in its receptor babo and its downstream mediator Smad2, all exhibit axon guidance defects that are similar to but less severe than tlr [2].
  • Furthermore, we show that dSMAD2 complexes with MEDEA only in the presence of ATR-I and PUNT. dSmad2 is expressed in the imaginal disks and in the outer proliferation centre of the larval brain, suggesting that it may have important proliferative and patterning roles during Drosophila development [3].
  • We show that dSmad2 induces activin responsive genes in Xenopus animal cap assays. dSMAD2 is phosphorylated by ATR-I and PUNT, but not by activated THICK VEINS, and translocates to the nucleus upon activation [3].
  • Twenty-seven genes are co-regulated 1.5 fold by both the tkv and babo pathways [4].

Biological context of babo


Analytical, diagnostic and therapeutic context of babo

  • CONCLUSIONS: Our genomic-wide microarray analysis has revealed common targets for the tkv and babo pathways and provided new insights into downstream effectors of two distinct TGFbeta like pathways [4].


  1. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Brummel, T., Abdollah, S., Haerry, T.E., Shimell, M.J., Merriam, J., Raftery, L., Wrana, J.L., O'Connor, M.B. Genes Dev. (1999) [Pubmed]
  2. The metalloprotease Tolloid-related and its TGF-{beta}-like substrate Dawdle regulate Drosophila motoneuron axon guidance. Serpe, M., O'connor, M.B. Development (2006) [Pubmed]
  3. Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Das, P., Inoue, H., Baker, J.C., Beppu, H., Kawabata, M., Harland, R.M., Miyazono, K., Padgett, R.W. Genes Cells (1999) [Pubmed]
  4. Genome-wide microarray analysis of TGFbeta signaling in the Drosophila brain. Yang, M., Nelson, D., Funakoshi, Y., Padgett, R.W. BMC Dev. Biol. (2004) [Pubmed]
  5. The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif. Lours, C., Bardot, O., Godt, D., Laski, F.A., Couderc, J.L. Nucleic Acids Res. (2003) [Pubmed]
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