Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Tgfbr1 - transforming growth factor, beta receptor 1

Rattus norvegicus

Synonyms: Alk5, SKR4, Serine/threonine-protein kinase receptor R4, Skr4, TGF-beta receptor type I, ...

Lai, X.N. et al., Morath, C. et al., Massagué, J. et al., Schaier, M. et al.

Lai, Wang, Zhu, Wang,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Tgfbr1

Cells and isolated membranes from human, rat, and mouse origin affinity labeled with 125I-beta TGF exhibit a major labeled species of approximately 280 kilodaltons that has the properties of high affinity and specificity expected from a physiologically relevant beta TGF receptor [1].
In all-trans retinoic acid-treated animals with Thy-GN, the increase of glomerular TGF-beta 1 protein (P < 0.008) and TGF-beta 1 (P < 0.025) and TGF receptor II mRNA (P < 0.015) was significantly less [2].
Cortical expression of TGF receptor II, but not receptor I gene expression, was significantly lower in animals treated with all-trans retinoic acid or isotretinoin (P < 0.05) [2].
Immunohistochemistry revealed less glomerular staining for TGF-beta 1 and TGF receptor II in the presence of all-trans retinoic acid [2].
OBJECTIVE: To investigate the effect of substance P (SP) on gene expression of transforming growth factor beta-1 (TGFbeta-1), transforming growth factor receptor-1 (TGFR-1) and transforming growth factor receptor-2 (TGFR-2) in fibroblasts cultured in vitro from rat's granulation tissues [3].

Anatomical context of Tgfbr1

RESULTS: The gene expression of TGFbeta-1, TGFR-1 and TGFR-2 in the fibroblasts cultured from rat's granulation tissues was up-regulated by SP [3].

Associations of Tgfbr1 with chemical compounds

The increase of transforming growth factor (TGF)-beta1, TGF receptor II and prepro-endothelin-1 gene expression in vehicle-treated nephritic rats was significantly attenuated by isotretinoin [4].

Other interactions of Tgfbr1

It was concluded that the beneficial effects of retinoids on glomerular damage are presumably due to a marked reduction in renal TGF-beta 1 and TGF receptor II expression [2].

Analytical, diagnostic and therapeutic context of Tgfbr1

When different concentrations (10(-9)-10(-5) mol/L) of SP were added into the culture medium, the changes of gene expression of TGFbeta-1, TGFR-1 and TGFR-2 in the cultured fibroblasts were observed with reverse transcription polymerase chain reaction at different intervals (0, 3, 6, 12 and 24 hours after incubation) [3].

References

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines. Massagué, J., Like, B. J. Biol. Chem. (1985) [Pubmed]
Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis. Morath, C., Dechow, C., Lehrke, I., Haxsen, V., Waldherr, R., Floege, J., Ritz, E., Wagner, J. J. Am. Soc. Nephrol. (2001) [Pubmed]
Effect of substance P on gene expression of transforming growth factor beta-1 and its receptors in rat's fibroblasts. Lai, X.N., Wang, Z.G., Zhu, J.M., Wang, L.L. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. (2003) [Pubmed]
Isotretinoin alleviates renal damage in rat chronic glomerulonephritis. Schaier, M., Lehrke, I., Schade, K., Morath, C., Shimizu, F., Kawachi, H., Grone, H.J., Ritz, E., Wagner, J. Kidney Int. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP008247	Anopheles gambiae str. PEST
AgaP_AGAP012476	Anopheles gambiae str. PEST
TGFBR1	Bos taurus
TGFBR1	Canis lupus familiaris
tgfbr1a	Danio rerio
tgfbr1b	Danio rerio
babo	Drosophila melanogaster
TGFBR1	Gallus gallus
TGFBR1	Homo sapiens
TGFBR1	Macaca mulatta
Tgfbr1	Mus musculus
TGFBR1	Pan troglodytes
tgfbr1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.