High impact information on Ostn

• Musclin mRNA levels in skeletal muscle were markedly low in fasted, increased upon re-feeding, and were low in streptozotocin-treated insulin-deficient mice [1].
• Musclin mRNA expression was induced at late stage in the differentiation of C2C12 myocytes [1].
• Musclin protein contained a region homologous to natriuretic peptide family, and KKKR, a putative serine protease cleavage site, similar to the natriuretic peptide family [1].
• Musclin expression level is tightly regulated by nutritional changes and its physiological role could be linked to glucose metabolism [1].
• Immunohistochemistry on adult mouse bone showed osteocrin localization in osteoblasts and young osteocytes [2].

Anatomical context of Ostn

• These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator [2].
• Musclin mRNA was expressed almost exclusively in the skeletal muscle of mice [1].

Analytical, diagnostic and therapeutic context of Ostn

• In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures [2].
• By Northern blot analysis, osteocrin expression was only detected in bone, expression peaking just after birth and decreasing markedly with age [2].

References