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Gene Review

OSTN  -  osteocrin

Homo sapiens

Synonyms: Musclin, Osteocrin
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High impact information on OSTN

  • The mammalian members are atrial natriuretic peptide, B-type natriuretic peptide, C-type natriuretic peptide, and possibly osteocrin/musclin [1].
  • In myocytes, insulin increased, while epinephrine, isoproterenol, and forskolin reduced musclin mRNA, all of which are known to increase the cellular content of cyclic AMP, a counter-regulator to insulin [2].
  • Here, we report the identification of a novel secretory factor, musclin, by signal sequence trap of mouse skeletal muscle cDNAs [2].
  • Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype [3].
  • Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose-dependent down-regulation of osteocrin expression, suggesting direct regulation [3].

Biological context of OSTN


Anatomical context of OSTN

  • Functionally, recombinant musclin significantly attenuated insulin-stimulated glucose uptake and glycogen synthesis in myocytes [2].
  • A single fiber analysis showed that musclin was produced by muscle fibers themselves, almost exclusively type IIb fibers [4].
  • In adult bone, Ostn expression was specifically localized to osteoblasts and young osteocytes at bone-forming sites [5].
  • Slow to fast transition of soleus phenotype after hindlimb suspension increased musclin mRNA levels, whereas fast to slow transition of plantaris phenotype after functional overload decreased musclin mRNA levels [4].

Associations of OSTN with chemical compounds

  • Low-dose estradiol decreased Ostn expression time dependently (p<0.05), whereas Ostn expression in cultures treated with high-dose estradiol was not significantly changed [5].
  • The PPARgamma Agonist Troglitazone Induces Musclin mRNA Expression in Human Myotubes [6].

Analytical, diagnostic and therapeutic context of OSTN


  1. Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. Potter, L.R., Abbey-Hosch, S., Dickey, D.M. Endocr. Rev. (2006) [Pubmed]
  2. Musclin, a novel skeletal muscle-derived secretory factor. Nishizawa, H., Matsuda, M., Yamada, Y., Kawai, K., Suzuki, E., Makishima, M., Kitamura, T., Shimomura, I. J. Biol. Chem. (2004) [Pubmed]
  3. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. Thomas, G., Moffatt, P., Salois, P., Gaumond, M.H., Gingras, R., Godin, E., Miao, D., Goltzman, D., Lanctôt, C. J. Biol. Chem. (2003) [Pubmed]
  4. Musclin gene expression is strongly related to fast-glycolytic phenotype. Banzet, S., Koulmann, N., Sanchez, H., Serrurier, B., Peinnequin, A., Bigard, A.X. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  5. Characterization of osteocrin expression in human bone. Bord, S., Ireland, D.C., Moffatt, P., Thomas, G.P., Compston, J.E. J. Histochem. Cytochem. (2005) [Pubmed]
  6. The PPARgamma Agonist Troglitazone Induces Musclin mRNA Expression in Human Myotubes. Staiger, H., Haas, C., Machicao, F., Häring, H.U. Horm. Metab. Res. (2006) [Pubmed]
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