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Gene Review:

NS1 - nonstructural protein 1

Influenza A virus (A/New York/392/2004(H3N2))

Hatada, E. et al., Hall, R.M. et al., Ferko, B. et al., Guo, Y.J. et al.

Ferko, Stasakova, Sereinig, Romanova, Katinger, Niebler, Katinger, Egorov,

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Disease relevance of NS1

Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses [1].
Nucleotide sequences have been determined for complementary DNA transcribed from the 3' ends of RNA segments 7 (matrix gene) and 8 (nonstructural gene) from a number of human influenza A viruses isolated over a period of 43 years and representing H0N1, H1N1, H2N2, and H3N2 subtypes [1].
Sequence differences amongst the neuraminidase, nucleoprotein and nonstructural genes of these three H1N2 reassortant viruses as well as the isolation of reassortants in seven laboratories over a 4 month period make it unlikely that the H1N2 viruses are laboratory artefacts [2].

High impact information on NS1

We have generated recombinant influenza A viruses belonging to the H1N1 and H3N2 virus subtypes containing an insertion of the 137 C-terminal amino acid residues of the human immunodeficiency virus type 1 (HIV-1) Nef protein into the influenza A virus nonstructural-protein (NS1) reading frame [3].
With both NS1 ts mutants, the synthesis of two late proteins, the matrix protein (M1) and haemagglutinin (HA), was greatly reduced and NS1 synthesis also decreased at 40 degrees C (non-permissive temperature) compared to that at 34 degrees C (permissive temperature) [4].
The H1 strains, ICR1629 and SPC45, have a single amino acid substitution in the coding region of the non-structural protein NS1, whereas the H2 strain, ICR516, has a substitution in the NS2-coding region [4].

References

Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses. Hall, R.M., Air, G.M. J. Virol. (1981) [Pubmed]
Human influenza A (H1N2) viruses isolated from China. Guo, Y.J., Xu, X.Y., Cox, N.J. J. Gen. Virol. (1992) [Pubmed]
Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice. Ferko, B., Stasakova, J., Sereinig, S., Romanova, J., Katinger, D., Niebler, B., Katinger, H., Egorov, A. J. Virol. (2001) [Pubmed]
Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8. Hatada, E., Hasegawa, M., Shimizu, K., Hatanaka, M., Fukuda, R. J. Gen. Virol. (1990) [Pubmed]

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