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Gene Review

Asx  -  Additional sex combs

Drosophila melanogaster

Synonyms: ASX, CG8787, Dmel\CG8787, FBgn0261823, Polycomb protein Asx, ...
 
 
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High impact information on Asx

 

Biological context of Asx

 

Regulatory relationships of Asx

  • Asx alleles enhance both PcG and trxG homeotic transformations, showing that Asx is required for both the activation and the repression of homeotic loci [4].
 

Other interactions of Asx

  • Asx and Pcl mutants show derepression of the targets only in specific cell types [5].
  • The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs [4].

References

  1. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Sinclair, D.A., Milne, T.A., Hodgson, J.W., Shellard, J., Salinas, C.A., Kyba, M., Randazzo, F., Brock, H.W. Development (1998) [Pubmed]
  2. Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster. Sinclair, D.A., Clegg, N.J., Antonchuk, J., Milne, T.A., Stankunas, K., Ruse, C., Grigliatti, T.A., Kassis, J.A., Brock, H.W. Genetics (1998) [Pubmed]
  3. Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family. Fisher, C.L., Randazzo, F., Humphries, R.K., Brock, H.W. Gene (2006) [Pubmed]
  4. The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Milne, T.A., Sinclair, D.A., Brock, H.W. Mol. Gen. Genet. (1999) [Pubmed]
  5. Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster. Soto, M.C., Chou, T.B., Bender, W. Genetics (1995) [Pubmed]
 
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