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Gene Review

Su(var)2-HP2  -  CG12864 gene product from transcript...

Drosophila melanogaster

Synonyms: CG12864, Dmel\CG12864, HP2, Hp2, SU(VAR)2-HP2
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High impact information on Su(var)2-HP2


Biological context of Su(var)2-HP2

  • We also demonstrate that Su(var)2-HP2 exhibits a dosage-dependent modification of variegation of a yellow reporter transgene, indicating a structural role in heterochromatin formation [2].
  • We show here that HP2 is present in the arms as well as the centromeric regions of mitotic chromosomes [2].
  • These mutations result in reduction of H3 Lys9 methylation and delocalization of HP1 and HP2, most dramatically in spindle-E mutants [4].

Associations of Su(var)2-HP2 with chemical compounds

  • In aqueous trifluoroethanol solution, HP2 folds into two structural units; the SPNQ part of each unit folds into a turn structure, while the C-terminal part shows some helical characteristics but is less structured [5].


  1. Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Shaffer, C.D., Stephens, G.E., Thompson, B.A., Funches, L., Bernat, J.A., Craig, C.A., Elgin, S.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. The Large Isoform of Drosophila melanogaster Heterochromatin Protein 2 Plays a Critical Role in Gene Silencing and Chromosome Structure. Shaffer, C.D., Cenci, G., Thompson, B., Stephens, G.E., Slawson, E.E., Adu-Wusu, K., Gatti, M., Elgin, S.C. Genetics (2006) [Pubmed]
  3. Four serine proteinases expressed in Manduca sexta haemocytes. Jiang, H., Wang, Y., Kanost, M.R. Insect Mol. Biol. (1999) [Pubmed]
  4. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Pal-Bhadra, M., Leibovitch, B.A., Gandhi, S.G., Rao, M., Bhadra, U., Birchler, J.A., Elgin, S.C. Science (2004) [Pubmed]
  5. Solution structure of the DNA binding octapeptide repeat of the K10 gene product. Suzuki, M., Neuhaus, D., Gerstein, M., Aimoto, S. Protein Eng. (1994) [Pubmed]
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