The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Su(var)2-HP2  -  CG12864 gene product from transcript...

Drosophila melanogaster

Synonyms: CG12864, Dmel\CG12864, HP2, Hp2, SU(VAR)2-HP2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Su(var)2-HP2

 

Biological context of Su(var)2-HP2

  • We also demonstrate that Su(var)2-HP2 exhibits a dosage-dependent modification of variegation of a yellow reporter transgene, indicating a structural role in heterochromatin formation [2].
  • We show here that HP2 is present in the arms as well as the centromeric regions of mitotic chromosomes [2].
  • These mutations result in reduction of H3 Lys9 methylation and delocalization of HP1 and HP2, most dramatically in spindle-E mutants [4].
 

Associations of Su(var)2-HP2 with chemical compounds

  • In aqueous trifluoroethanol solution, HP2 folds into two structural units; the SPNQ part of each unit folds into a turn structure, while the C-terminal part shows some helical characteristics but is less structured [5].

References

  1. Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Shaffer, C.D., Stephens, G.E., Thompson, B.A., Funches, L., Bernat, J.A., Craig, C.A., Elgin, S.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. The Large Isoform of Drosophila melanogaster Heterochromatin Protein 2 Plays a Critical Role in Gene Silencing and Chromosome Structure. Shaffer, C.D., Cenci, G., Thompson, B., Stephens, G.E., Slawson, E.E., Adu-Wusu, K., Gatti, M., Elgin, S.C. Genetics (2006) [Pubmed]
  3. Four serine proteinases expressed in Manduca sexta haemocytes. Jiang, H., Wang, Y., Kanost, M.R. Insect Mol. Biol. (1999) [Pubmed]
  4. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Pal-Bhadra, M., Leibovitch, B.A., Gandhi, S.G., Rao, M., Bhadra, U., Birchler, J.A., Elgin, S.C. Science (2004) [Pubmed]
  5. Solution structure of the DNA binding octapeptide repeat of the K10 gene product. Suzuki, M., Neuhaus, D., Gerstein, M., Aimoto, S. Protein Eng. (1994) [Pubmed]
 
WikiGenes - Universities