The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Isoform     1-iodo-4-methoxy-benzene

Synonyms: p-Iodoanisole, PubChem3911, SureCN24567, I7608_ALDRICH, AGN-PC-00CFDO, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Isoform


Psychiatry related information on Isoform


High impact information on Isoform


Biological context of Isoform


Anatomical context of Isoform


Associations of Isoform with other chemical compounds


Gene context of Isoform


Analytical, diagnostic and therapeutic context of Isoform

  • The size difference was also confirmed in Western blots using a monoclonal antibody which binds to both Is and Ic [32].
  • 7. Both Isoform types are predictive of AMI by the gold standard, and addition of EKG changes results in a small improvement [33].


  1. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Carta, C., Pantaleoni, F., Bocchinfuso, G., Stella, L., Vasta, I., Sarkozy, A., Digilio, C., Palleschi, A., Pizzuti, A., Grammatico, P., Zampino, G., Dallapiccola, B., Gelb, B.D., Tartaglia, M. Am. J. Hum. Genet. (2006) [Pubmed]
  2. Immunologic identification of Na+,K(+)-ATPase isoforms in myocardium. Isoform change in deoxycorticosterone acetate-salt hypertension. Sweadner, K.J., Herrera, V.L., Amato, S., Moellmann, A., Gibbons, D.K., Repke, K.R. Circ. Res. (1994) [Pubmed]
  3. CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV-1 Encephalitis. Cosenza-Nashat, M.A., Kim, M.O., Zhao, M.L., Suh, H.S., Lee, S.C. Brain Pathol. (2006) [Pubmed]
  4. Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease-Like Myeloid Leukemia. Cadieux, C., Fournier, S., Peterson, A.C., B??dard, C., Bedell, B.J., Nepveu, A. Cancer Res. (2006) [Pubmed]
  5. Deletion of Protein Kinase C-{beta} Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model. Meier, M., Park, J.K., Overheu, D., Kirsch, T., Lindschau, C., Gueler, F., Leitges, M., Menne, J., Haller, H. Diabetes (2007) [Pubmed]
  6. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. Sanan, D.A., Weisgraber, K.H., Russell, S.J., Mahley, R.W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., Roses, A.D. J. Clin. Invest. (1994) [Pubmed]
  7. Isolation of multiple normal and functionally defective forms of uridine diphosphate-glucuronosyltransferase from inbred Gunn rats. Roy Chowdhury, N., Gross, F., Moscioni, A.D., Kram, M., Arias, I.M., Roy Chowdhury, J. J. Clin. Invest. (1987) [Pubmed]
  8. The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. Cuff, M., Dyer, J., Jones, M., Shirazi-Beechey, S. Gastroenterology (2005) [Pubmed]
  9. Differentiation-Induced Cleavage of Cutl1/CDP Generates a Novel Dominant-Negative Isoform That Regulates Mammary Gene Expression. Maitra, U., Seo, J., Lozano, M.M., Dudley, J.P. Mol. Cell. Biol. (2006) [Pubmed]
  10. The Slow Skeletal Muscle Isoform of Myosin Shows Kinetic Features Common to Smooth and Non-muscle Myosins. Iorga, B., Adamek, N., Geeves, M.A. J. Biol. Chem. (2007) [Pubmed]
  11. Phosphorylation of a Threonine Unique to the Short C-terminal Isoform of betaII-Spectrin Links Regulation of {alpha}-beta Spectrin Interaction to Neuritogenesis. Bignone, P.A., King, M.D., Pinder, J.C., Baines, A.J. J. Biol. Chem. (2007) [Pubmed]
  12. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. Elenius, K., Corfas, G., Paul, S., Choi, C.J., Rio, C., Plowman, G.D., Klagsbrun, M. J. Biol. Chem. (1997) [Pubmed]
  13. The Large Isoform of Drosophila melanogaster Heterochromatin Protein 2 Plays a Critical Role in Gene Silencing and Chromosome Structure. Shaffer, C.D., Cenci, G., Thompson, B., Stephens, G.E., Slawson, E.E., Adu-Wusu, K., Gatti, M., Elgin, S.C. Genetics (2006) [Pubmed]
  14. Proteasome Inhibitors Potentiate Etoposide-Induced Cell Death in Human Astrocytoma Cells Bearing a Mutated p53 Isoform. Ceruti, S., Mazzola, A., Abbracchio, M.P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  15. Upregulation of HERG Channels by the Serum and Glucocorticoid Inducible Kinase Isoform SGK3. Maier, G., Palmada, M., Rajamanickam, J., Shumilina, E., Bohmer, C., Lang, F. Cell. Physiol. Biochem. (2006) [Pubmed]
  16. IF3, a novel cell-differentiation factor, highly expressed in murine liver and ovary. Mano, H., Nakatani, S., Aoyagi, R., Ishii, R., Iwai, Y., Shimoda, N., Jincho, Y., Hiura, H., Hirose, M., Mochizuki, C., Yuri, M., Hyock Im, R., Funada-Wada, U., Wada, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  17. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes. Goodnight, J.A., Mischak, H., Kolch, W., Mushinski, J.F. J. Biol. Chem. (1995) [Pubmed]
  18. Cutting Edge: Hypoxia-Inducible Factor 1{alpha} and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes. Lukashev, D., Klebanov, B., Kojima, H., Grinberg, A., Ohta, A., Berenfeld, L., Wenger, R.H., Ohta, A., Sitkovsky, M. J. Immunol. (2006) [Pubmed]
  19. Identification and characterization of protein kinase CKII isoforms in HeLa cells. Isoform-specific differences in rates of assembly from catalytic and regulatory subunits. Chester, N., Yu, I.J., Marshak, D.R. J. Biol. Chem. (1995) [Pubmed]
  20. gamma Isoform-selective changes in PKC immunoreactivity after trace eyeblink conditioning in the rabbit hippocampus. Van der Zee, E.A., Kronforst-Collins, M.A., Maizels, E.T., Hunzicker-Dunn, M., Disterhoft, J.F. Hippocampus. (1997) [Pubmed]
  21. Alteration of the isoform composition of plasma-membrane-associated rat sperm alpha-L-fucosidase during late epididymal maturation: comparative characterization of the acidic and neutral isoforms. Abascal, I., Skalaban, S.R., Grimm, K.M., Avilés, M., Martianez-Menarguez, J.A., Castells, M.T., Ballesta, J., Alhadeff, J.A. Biochem. J. (1998) [Pubmed]
  22. New Tick Defensin Isoform and Antimicrobial Gene Expression in Response to Rickettsia montanensis Challenge. Ceraul, S.M., Dreher-Lesnick, S.M., Gillespie, J.J., Rahman, M.S., Azad, A.F. Infect. Immun. (2007) [Pubmed]
  23. Mechanism of Calmodulin Recognition of the Binding Domain of Isoform 1b of the Plasma Membrane Ca(2+)-ATPase: Kinetic Pathway and Effects of Methionine Oxidation. Slaughter, B.D., Urbauer, R.J., Urbauer, J.L., Johnson, C.K. Biochemistry (2007) [Pubmed]
  24. Differential Effects of Systemic Ethanol Administration on Protein Kinase C{epsilon}, {gamma}, and beta Isoform Expression, Membrane Translocation, and Target Phosphorylation: Reversal by Chronic Ethanol Exposure. Kumar, S., Lane, B.M., Morrow, A.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  25. Albumin and glucose effects on cell growth parameters, albumin uptake and Na(+)/H(+)-exchanger Isoform 3 in OK cells. Drumm, K., Lee, E., Stanners, S., Gassner, B., Gekle, M., Poronnik, P., Pollock, C. Cell. Physiol. Biochem. (2003) [Pubmed]
  26. Glucocorticoid Regulation of GLT-1 Glutamate Transporter Isoform Expression in the Rat Hippocampus. Autry, A.E., Grillo, C.A., Piroli, G.G., Rothstein, J.D., McEwen, B.S., Reagan, L.P. Neuroendocrinology (2006) [Pubmed]
  27. A Truncated Alternative Spliced Isoform of Human Desmoglein 1 Contains a Specific T Cell Epitope Binding to the Pemphigus Foliaceus-Associated HLA Class II DRbeta1*0102 Molecule. Mouquet, H., Farci, S., Joly, P., Maill??re, B., Leblond, J., Drouot, L., Leprince, J., Tonon, M.C., Loiseau, P., Charron, D., Tron, F., Gilbert, D. J. Immunol. (2006) [Pubmed]
  28. In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Ko, J.W., Desta, Z., Soukhova, N.V., Tracy, T., Flockhart, D.A. British journal of clinical pharmacology. (2000) [Pubmed]
  29. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Bäckman, C.M., Shan, L., Zhang, Y.J., Hoffer, B.J., Leonard, S., Troncoso, J.C., Vonsatel, P., Tomac, A.C. Mol. Cell. Endocrinol. (2006) [Pubmed]
  30. theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. Banan, A., Zhang, L.J., Shaikh, M., Fields, J.Z., Choudhary, S., Forsyth, C.B., Farhadi, A., Keshavarzian, A. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  31. Identification of two testosterone-responsive testicular proteins in Sertoli cell-enriched culture medium whose secretion is suppressed by cells of the intact seminiferous tubule. Cheng, C.Y., Bardin, C.W. J. Biol. Chem. (1987) [Pubmed]
  32. Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues. Spencer, G.G., Yu, X.H., Khan, I., Grover, A.K. Biochim. Biophys. Acta (1991) [Pubmed]
  33. Clinical utility of CKMB isoform determinations in patients who present to the emergency department with continuous or resolved chest pain. Morris, S.A., Helmer, D., Pesce, M., Giglio, J. The Journal of emergency medicine. (2000) [Pubmed]
WikiGenes - Universities