High impact information on RpLP2

• Antisense rpA1 expression severely disrupted oogenesis and produced a "small egg" female-sterile phenotype [1].
• To assess the functional importance of ribosomal protein rpA1 gene expression during development of Drosophila melanogaster, we have transformed into the fly's genome an antisense rpA1 gene driven by a heat shock promoter [1].
• CONCLUSIONS: Temporal coordination of mitotic events involves inhibition of cytokinesis by cyclin B and cyclin B3 and punctual relief of the inhibition by destruction of these cyclins [2].
• Cis-acting sequences in the 5'-untranslated region of the ribosomal protein A1 mRNA mediate its translational regulation during early embryogenesis of Drosophila [3].
• Chimeric genes containing sequences from the translationally regulated rpA1 mRNA fused to the constitutively translated alpha-tubulin mRNA were constructed and transformed into the Drosophila germ line [3].

Biological context of RpLP2

• A cloned DNA sequence coding for rpA1 has been identified by hybrid-selected translation and amino acid composition analysis [4].
• The rpA1 gene was localized to polytene chromosome band 53CD [4].

References