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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ptf1a  -  pancreas specific transcription factor, 1a

Danio rerio

Synonyms: PTF1, Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, SO:0000704, bHLH transcription factor p48, ...
 
 
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High impact information on ptf1a

  • Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas [1].
  • Within the endoderm, ptf1a is initially expressed at 32 hpf in the ventral portion of the pdx1 expression domain; ptf1a is expressed in a subset of cells located on the left side of the embryo posteriorly to the liver primordium and anteriorly to the endocrine islet that arises from the posterodorsal pancreatic anlage [2].
  • Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas [3].
  • Early zebrafish ptf1a expression is observed in developing hindbrain and in endodermal pancreatic precursors [3].
  • In addition to the exocrine phenotype, ptf1a knockdown also reduces the prevalence of a small population of anterior endocrine cells normally found outside the principal islet [3].
 

Other interactions of ptf1a

  • In mind bomb (mib) mutants, in which delta-mediated notch signalling is defective [Dev. Cell 4 (2003) 67], ptf1a is normally expressed [2].

References

  1. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Esni, F., Ghosh, B., Biankin, A.V., Lin, J.W., Albert, M.A., Yu, X., MacDonald, R.J., Civin, C.I., Real, F.X., Pack, M.A., Ball, D.W., Leach, S.D. Development (2004) [Pubmed]
  2. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Zecchin, E., Mavropoulos, A., Devos, N., Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M., Argenton, F. Dev. Biol. (2004) [Pubmed]
  3. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Lin, J.W., Biankin, A.V., Horb, M.E., Ghosh, B., Prasad, N.B., Yee, N.S., Pack, M.A., Leach, S.D. Dev. Biol. (2004) [Pubmed]
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