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Gene Review

ORF1b  -  RdRP

Grapevine leafroll-associated virus 2

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Disease relevance of ORF1b


High impact information on ORF1b

  • This genome organization is typical of the monopartite closteroviruses, including the putative +1 ribosomal frameshift allowing expression of ORF1b [5].
  • In the positive-stranded RNA genome of beet yellows closterovirus (BYV), the 5'-terminal ORF 1a encodes a 295 kDa polyprotein with the domains of papain-like cysteine proteinase, methyltransferase (MT) and helicase (HEL), whereas ORF 1b encodes an RNA-dependent RNA polymerase [6].
  • Computer-assisted analysis of LIYV RNA 1 ORFs identified domains for a papain-like protease, methyltransferase (MTR), RNA helicase (HEL), and RNA-dependent RNA polymerase (RdRp) [4].
  • An incomplete ORF, ORF1, encoded the C-terminal part of a putative RNA-dependent RNA polymerase, most closely related to polymerases of tricornaviruses; the putative product of ORF3, 65K, was found to be a homologue of the hsp70 family of cell heat-shock proteins [7].

Biological context of ORF1b


  1. Nucleotide sequence of the 3'-terminal two-thirds of the grapevine leafroll-associated virus-3 genome reveals a typical monopartite closterovirus. Ling, K.S., Zhu, H.Y., Drong, R.F., Slightom, J.L., McFerson, J.R., Gonsalves, D. J. Gen. Virol. (1998) [Pubmed]
  2. Beet yellows closterovirus: complete genome structure and identification of a leader papain-like thiol protease. Agranovsky, A.A., Koonin, E.V., Boyko, V.P., Maiss, E., Frötschl, R., Lunina, N.A., Atabekov, J.G. Virology (1994) [Pubmed]
  3. Complete sequence of the citrus tristeza virus RNA genome. Karasev, A.V., Boyko, V.P., Gowda, S., Nikolaeva, O.V., Hilf, M.E., Koonin, E.V., Niblett, C.L., Cline, K., Gumpf, D.J., Lee, R.F. Virology (1995) [Pubmed]
  4. Genome structure and phylogenetic analysis of lettuce infectious yellows virus, a whitefly-transmitted, bipartite closterovirus. Klaassen, V.A., Boeshore, M.L., Koonin, E.V., Tian, T., Falk, B.W. Virology (1995) [Pubmed]
  5. Nucleotide sequence, genome organization and phylogenetic analysis of pineapple mealybug wilt-associated virus-2. Melzer, M.J., Karasev, A.V., Sether, D.M., Hu, J.S. J. Gen. Virol. (2001) [Pubmed]
  6. Detection of beet yellows closterovirus methyltransferase-like and helicase-like proteins in vivo using monoclonal antibodies. Erokhina, T.N., Zinovkin, R.A., Vitushkina, M.V., Jelkmann, W., Agranovsky, A.A. J. Gen. Virol. (2000) [Pubmed]
  7. Nucleotide sequence of the 3'-terminal half of beet yellows closterovirus RNA genome: unique arrangement of eight virus genes. Agranovsky, A.A., Boyko, V.P., Karasev, A.V., Lunina, N.A., Koonin, E.V., Dolja, V.V. J. Gen. Virol. (1991) [Pubmed]
  8. Nucleotide sequence and genome organization of grapevine leafroll-associated virus-2 are similar to beet yellows virus, the closterovirus type member. Zhu, H.Y., Ling, K.S., Goszczynski, D.E., McFerson, J.R., Gonsalves, D. J. Gen. Virol. (1998) [Pubmed]
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