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MeSH Review


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Disease relevance of Closterovirus

  • Alignment of the putative P-PRO sequences of CTV with the related proteases of beet yellows closterovirus (BYV) and potyviruses allowed the prediction of catalytic cysteine and histidine residues as well as two cleavage sites, namely Val-Gly/Gly for the 5' proximal P-PRO domain and Met-Gly/Gly for the 5' distal P-PRO domain [1].
  • Phylogenetic analysis of the three replication-associated domains, MT, HEL, and RdRp, indicates that CTV and BYV form a separate closterovirus lineage within the alpha-like supergroup of positive-strand RNA viruses [1].
  • Full-length cloned cDNAs of lettuce infectious yellows closterovirus (LIYV) RNAs 1 and 2 were constructed and fused to the bacteriophage T3 RNA polymerase promoter [2].
  • In transient coexpression with viral membrane proteins tagged with GFP, DsRed-TGBp3 directed to the peripheral bodies the homologous TGBp2 protein and two unrelated membrane proteins, the 6 kDa movement protein of beet yellows closterovirus and the putative movement protein encoded by the genome component 4 of faba bean necrotic yellows nanovirus [3].
  • The suppressors p19 from tombusvirus and p21 from Beet yellows virus appear to block silencing by directly binding siRNA, a critical mediator in the process [4].

High impact information on Closterovirus


Chemical compound and disease context of Closterovirus


Biological context of Closterovirus

  • Computer-assisted analysis revealed a striking sequence similarity between the putative 24-kDa protein (p24) encoded by open reading frame (ORF) 5 of beet yellows closterovirus and the coat protein of this virus encoded by the adjacent ORF6 [5].

Gene context of Closterovirus

  • A specific four-gene module consisting of the hsp70 protein, the hsp90-related protein, the diverged copy of the CP, and the CP itself was found to be common in organization between CTV and beet yellows closterovirus [11].
  • RNA silencing suppressor p21 of Beet yellows virus forms an RNA binding octameric ring structure [4].


  1. Complete sequence of the citrus tristeza virus RNA genome. Karasev, A.V., Boyko, V.P., Gowda, S., Nikolaeva, O.V., Hilf, M.E., Koonin, E.V., Niblett, C.L., Cline, K., Gumpf, D.J., Lee, R.F. Virology (1995) [Pubmed]
  2. In vitro transcripts from cloned cDNAs of the lettuce infectious yellows closterovirus bipartite genomic RNAs are competent for replication in Nicotiana benthamiana protoplasts. Klaassen, V.A., Mayhew, D., Fisher, D., Falk, B.W. Virology (1996) [Pubmed]
  3. Dual-colour imaging of membrane protein targeting directed by poa semilatent virus movement protein TGBp3 in plant and mammalian cells. Zamyatnin, A.A., Solovyev, A.G., Sablina, A.A., Agranovsky, A.A., Katul, L., Vetten, H.J., Schiemann, J., Hinkkanen, A.E., Lehto, K., Morozov, S.Y. J. Gen. Virol. (2002) [Pubmed]
  4. RNA silencing suppressor p21 of Beet yellows virus forms an RNA binding octameric ring structure. Ye, K., Patel, D.J. Structure (Camb.) (2005) [Pubmed]
  5. Coat protein gene duplication in a filamentous RNA virus of plants. Boyko, V.P., Karasev, A.V., Agranovsky, A.A., Koonin, E.V., Dolja, V.V. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Movement protein of a closterovirus is a type III integral transmembrane protein localized to the endoplasmic reticulum. Peremyslov, V.V., Pan, Y.W., Dolja, V.V. J. Virol. (2004) [Pubmed]
  7. Interaction between long-distance transport factor and Hsp70-related movement protein of Beet yellows virus. Prokhnevsky, A.I., Peremyslov, V.V., Napuli, A.J., Dolja, V.V. J. Virol. (2002) [Pubmed]
  8. Putative 65 kDa protein of beet yellows closterovirus is a homologue of HSP70 heat shock proteins. Agranovsky, A.A., Boyko, V.P., Karasev, A.V., Koonin, E.V., Dolja, V.V. J. Mol. Biol. (1991) [Pubmed]
  9. Processing and subcellular localization of the leader papain-like proteinase of Beet yellows closterovirus. Zinovkin, R.A., Erokhina, T.N., Lesemann, D.E., Jelkmann, W., Agranovsky, A.A. J. Gen. Virol. (2003) [Pubmed]
  10. A spot multiplex nested RT-PCR for the simultaneous and generic detection of viruses involved in the aetiology of grapevine leafroll and rugose wood of grapevine. Dovas, C.I., Katis, N.I. J. Virol. Methods (2003) [Pubmed]
  11. Nucleotide sequence and organization of eight 3' open reading frames of the citrus tristeza closterovirus genome. Pappu, H.R., Karasev, A.V., Anderson, E.J., Pappu, S.S., Hilf, M.E., Febres, V.J., Eckloff, R.M., McCaffery, M., Boyko, V., Gowda, S. Virology (1994) [Pubmed]
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