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Gene Review:

Dp1 - Dodeca-satellite-binding protein 1

Drosophila melanogaster

Synonyms: BcDNA:LD21383, BcDNA:LD21677, CG5170, DDP1, Dmel\CG5170, ...

Cortés, A. et al., Cortés, A. et al., Cortés, A. et al.

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High impact information on Dp1

In polytene chromosomes, DDP1 is found located at the chromocentre associated with the pericentric heterochromatin but its distribution is not constrained to the dodeca-satellite sequences [1].
DDP1 also localizes to heterochromatin in interphase nuclei of larval neuroblasts [1].
DDP1 also showed a significant affinity for the unstructured pyrimidine-rich strand of the most abundant centromeric Drosophila AAGAG satellite [2].
DDP1, a heterochromatin-associated multi-KH-domain protein of Drosophila melanogaster, interacts specifically with centromeric satellite DNA sequences [2].
In particular, a guanine residue which is highly conserved in natural dodeca-satellite sequences was found to be essential for the efficient binding of DDP1 [2].

Biological context of Dp1

DDP1 contains 15 consecutive KH domains and is homologous to the highly conserved vigilin proteins that, in Saccharomyces cerevisiae, are involved in the control of cell ploidy [2].
A single-stranded nucleic acids binding protein, DDP1, binds the unstructured dodeca-satellite Y-strand with high affinity [3].

Co-localisations of Dp1

In addition to its localization at the chromocentre, in polytene chromosomes, DDP1 is also detected at several sites in the euchromatic arms co-localizing with the heterochromatin protein HP1 [1].

References

DDP1, a single-stranded nucleic acid-binding protein of Drosophila, associates with pericentric heterochromatin and is functionally homologous to the yeast Scp160p, which is involved in the control of cell ploidy. Cortés, A., Huertas, D., Fanti, L., Pimpinelli, S., Marsellach, F.X., Piña, B., Azorín, F. EMBO J. (1999) [Pubmed]
DDP1, a heterochromatin-associated multi-KH-domain protein of Drosophila melanogaster, interacts specifically with centromeric satellite DNA sequences. Cortés, A., Azorín, F. Mol. Cell. Biol. (2000) [Pubmed]
Analysing the contribution of nucleic acids to the structure and properties of centric heterochromatin. Cortés, A., Huertas, D., Marsellach, F.X., Ferrer-Miralles, N., Ortiz-Lombardía, M., Fanti, L., Pimpinelli, S., Piña, B., Azorín, F. Genetica (2003) [Pubmed]

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