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Gene Review:

DIO2 - deiodinase, iodothyronine, type II

Gallus gallus

Verhoelst, C.H. et al., Shen, S. et al.

Verhoelst, Darras, Roelens, Artykbaeva, Van der Geyten,

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Disease relevance of DIO2

These results indicate that the inadequate expression of DIO2 in the growth plates contributes to the pathogenesis of TD in broilers and that TD is a tissue-specific hypothyroidism [1].

High impact information on DIO2

Type II iodothyronine deiodinase protein in chicken choroid plexus: additional perspectives on T3 supply in the avian brain [2].
It is widely accepted that type II iodothyronine deiodinase (D2) is mostly present in the brain, where it maintains the homeostasis of thyroid hormone (TH) levels [2].

References

Differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia. Shen, S., Berry, W., Jaques, S., Pillai, S., Zhu, J. Anim. Genet. (2004) [Pubmed]
Type II iodothyronine deiodinase protein in chicken choroid plexus: additional perspectives on T3 supply in the avian brain. Verhoelst, C.H., Darras, V.M., Roelens, S.A., Artykbaeva, G.M., Van der Geyten, S. J. Endocrinol. (2004) [Pubmed]

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